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| 芳香化酶抑制剂的研究进展 | |
| 引用本文： | 崔中立,张沐新,杨晓虹,王广树. 芳香化酶抑制剂的研究进展[J]. 中国药物化学杂志, 2010, 19(1): 70-76 |
| 作者姓名： | 崔中立 张沐新 杨晓虹 王广树 |
| 作者单位： | 吉林大学 药学院，吉林 长春 130021 |
| 摘 要： | 芳香化酶是雌激素生物合成过程中的一个关键酶，抑制芳香化酶的活性就可以抑制雌激素的生成，从而减少绝经后妇女乳腺癌等疾病的发病率。以芳香化酶为靶标的研究一直都是抑制剂研究的热点，目前已有多个芳香化酶抑制剂进入临床试验阶段或已上市，该文对近年来芳香化酶抑制剂的研究进行综述。 |
| 关 键 词： | 药物化学；雌激素；芳香化酶抑制剂 |
| 收稿时间： | 2009-04-10 |
| 修稿时间： | 2009-10-07 |
Recent development in the studies on aromatase inhibitors |
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| CUI Zhong-li,ZHANG Mu-xin,YANG Xiao-hong,WANG Guang-shu. Recent development in the studies on aromatase inhibitors[J]. Chinese Journal of Medicinal Chemistry, 2010, 19(1): 70-76 | |
| Authors: | CUI Zhong-li ZHANG Mu-xin YANG Xiao-hong WANG Guang-shu |
| Affiliation: | School of Pharmacy, Jilin University, Changchun 130021, China |
| Abstract: | Aromatase is the key enzyme in estrogen biosynthesis. Aromatase inhibitors, by means of inhibiting the process of estrogen biosynthesis, are proved to be effective in breast cancer and other diseases occured in postmenopausal women. Therefore, scientific research have been carried out on new aromatase inhibitors, some of which have been taken into clinical trials or market. Recent development of aromatase inhibitors were reviewed. |
| Keywords: | medicinal chemistry estrogen aromatase inhibitor |
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