左氧氟沙星与阿莫西林／克拉维酸钾联合克拉霉素治疗社区获得性肺炎的临床随机对照研究

目的比较左氧氟沙星与阿莫西林／克拉维酸钾联合克拉霉素治疗社区获得性肺炎（CAP）的临床疗效。方法60例CAP患者随机分为左氧氟沙星组（A组）和阿莫西林／克拉维酸钾联合克拉霉素组（B组）各30例。A组给予500mg左氧氟沙星静脉注射，1次／d；当病情好转时改为500mg口服，1次，d。B组给予阿莫西林／克拉维酸钾（500mg／100mg）静脉注射，3次，d，同时口服克拉霉素500mg，2次／d；当病情好转后，改为口服阿莫西林／克拉维酸钾（250mg／125mg），3次，d，克拉霉素500mg，2次／d。治疗疗程为7～14d。结果A组和B组的临床总有效率分别为93.3％和96．7％，细菌清除率分别为73.3％和60．0％，差异均无统计学意义（P〉0．05）。两组不良反应轻微，差异无统计学意义（P〉0．05）。结论左氧氟沙星与阿莫西林／克拉维酸钾联合克拉霉素治疗CAP均安全有效，均可以作为CAP的首选药物。

Randomized comparative study of levofloxacin and amoxicillin/clavulanate plus clarithromycin in treatment of patients with community-acquired pneumonia

Objective To compare the clinical effects of levofloxacin and amoxicillin/clavulanate plus clarithromycin in treatment of patients with community acquired pneumonia(CAP).Methods Sixty patients with CAP were randomly divided into levofloxacin group(group A) and amoxicillin/clavulanate plus clarithromycin group(group B),respectively and each group consisted of 30 patients.Group A received 500 mg IV q24h transitioning to oral levofloxacin 500 mg q24h when the patients’ conditions were changed.Group B received amoxicillin/clavulanate 500 mg/100 mg IV q8h with oral clarithromycin 500 mg q12h and then switched to oral amoxicillin/clavulanate 250 mg/125 mg q8h with oral clarithromycin 500 mg q12h.The course of treatment was taken for a total of 7 to 14 days.Results The total effective rates of group B and group A were 93.3% and 96.7%;the bacteria eradication rates were 73.3% and 60.0% respectively,and there were no statistically significant difference(P > 0.05).The adverse reactions of two groups were slight and there was no statistically significant difference(P > 0.05).Conclusion It is safe and good for levofloxacin and amoxicillin/clavulanate plus clarithromycin for treatment of patients with CAP,and they all can be used as first choice drugs of CAP.