| Noxa的促凋亡作用与肿瘤关系的研究进展 |
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| 引用本文： | 马薇,王玉明,段勇.Noxa的促凋亡作用与肿瘤关系的研究进展[J].医学综述,2010,16(4). |
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| 作者姓名： | 马薇 王玉明 段勇 |
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| 作者单位： | 昆明医学院第一附属医院检验科,昆明,650032 |
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| 摘 要： | Noxa是Bcl-2家族中促凋亡的BH3-only亚家族成员之一,是p53的下游靶基因,其表达主要受p53调控。它定位于线粒体,其BH-3结构域主要与Mcl-1结合,启动caspase级联反应,诱导细胞凋亡。Noxa可以通过p53依赖途径及p53非依赖途径促进细胞凋亡,在肿瘤的形成和治疗中发挥着重要作用。
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| 关 键 词： | Noxa p53 凋亡 肿瘤 |
Progress on Pro-Apoptotic Effect of Noxa on Tumor |
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| MA Wei,WANG Yu-ming,DUAN Yong.Progress on Pro-Apoptotic Effect of Noxa on Tumor[J].Medical Recapitulate,2010,16(4). |
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| Authors: | MA Wei WANG Yu-ming DUAN Yong |
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| Institution: | MA Wei,WANG Yu-ming,DUAN Yong.(Inspection Division,the First Affiliated Hospital of Kunming Medical College,Kunming 650032,China) |
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| Abstract: | Noxa is a member of pro-apoptotic BH3-only subfamily in Bcl-2 family,it is a p53 downstream target gene,whose expression was mainly regulated by p53.It is located in mitochondria,the BH-3 domain on Noxa is mainly bind with Mcl-1,thus start the caspase cascade and induce cell apoptosis.Noxa promote apoptosis via p53-dependent and p53-independent mechanisms,it plays a prominent role in the formation and treatment of tumors. |
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| Keywords: | Noxa pS3 |
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