正畸牙移动与月经周期关系的实验研究

目的:探讨月经周期不同阶段加力正畸牙移动速度的差异及正畸治疗对月经周期的影响。方法:建立在Wistar雌性大鼠动情周期不同阶段给予正畸加力的实验模型,测量记录相应的牙移动距离差异,放射免疫法测定不同阶段血清中雌二醇的含量变化。采用SPSS11．0软件包,以单因素方差分析法比较动情周期同一阶段加力实验组与对照组的差异,以Student-Newman-Keuls(S-N-K)法进行同一组内动情周期不同阶段各亚组间的两两比较,同时采用余弦节律分析法进行血清雌激素含量变化节律的时间生物学分析。结果:大鼠动情周期不同阶段血清雌二醇含量存在近5天的节律变化,其中在动情期最低(P<0．05),此时加力牙移动速度最快(P<0．05),移动距离为(2．10±0．14)mm;在动情前期最高(P<0．05),牙移动最慢(P<0．05),移动距离为(1.79+0．03)mm。正畸加力使大鼠血清雌二醇浓度升高,但未改变其节律性波动的变化规律。结论:女性正畸患者可能存在一个牙移动最快的最佳加力时机,在雌激素水平最低的月经来潮前给予正畸加力,可能会获得最快的牙移动效果。

An experimental study on the relationship between the orthodontic tooth movements and menstrual cycle

PURPOSE: The purpose of this study was to explore the relationship between the menstrual cycle and orthodontic tooth movement. METHODS: A Wistar rat model was established to apply orthodontic activation during different stages of the estrous cycle. The distances of the tooth movements were measured and the serum estradiol level was detected by radioimmunoassay. The data of each group was analyzed with SPSS11.0 software package for Student-Newman-Keuls(S-N-K)test and one way ANOVA test. And cosinor-rhythmometry method was used for chronobiologic analysis to show the rhythmic change of the serum estradiol level. RESULTS: There was a 5-day rhythm of the rat serum estradiol during the estrous cycle. The distances of orthodontic tooth movement were different at various stages. Teeth moved fastest in the estrus while the serum estradiol was lowest (P<0.05), the distance of tooth moved was (2.10+/-0.14)mm. And teeth moved slowest in the proestrus while the serum estradiol was highest (P+/-0.05), the distance of tooth moved was (1.79+/-0.03)mm. Totally, orthodontic activation increased the serum estradiol level without disturbing its fluctuating rhythm. CONCLUSION: It was inferred that female patients may have an optimal opportunity of orthodontic activation for rapid tooth movement, which should be applied on a few days before the menorrhea in order to move the teeth rapidly.