血清和脑脊液中IL-6含量变化在儿童难治性癫痫发作中的意义

目的探讨白细胞介素-6(IL-6)与小儿难治性癫痫发病机制之间的潜在关系。方法采用酶联免疫吸附法检测48例小儿难治性癫痫患者癫痫发作后血清和脑脊液中IL-6的含量变化。结果癫痫发作1、6 h后,癫痫组患者血清IL-6水平分别为(8.23±0.58)、(11.63±1.35)pg/ml,与正常对照组(0.75±0.48)pg/ml相比有统计学意义(P<0.05,P<0.01);癫痫发作1、6 h后,脑脊液中IL-6水平亦逐渐升高,分别为(10.35±3.06)、(19.55±2.32)pg/ml,显著高于正常对照组(1.27±0.65)pg/ml,P<0.01];而发作后12 h,癫痫组患者血清和脑脊液中的IL-6含量趋于正常分别为(1.05±0.66)、(3.54±1.31)pg/ml],与正常对照组相比无显著差异(P>0.05)。结论癫痫发作可诱导血清和脑脊液中IL-6表达水平的上调,这可能促进炎性损伤的进一步加重,可能与小儿难治性癫痫的病情进展密切相关。

Significance of interleukin-6 levels in serum and cerebrospinal fluid for pediatric intractable epilepsy

Objective To explore the potential relationship between the level of IL-6 in the serum and cerebrospinal fluid(CSF) and epileptogenesis of pediatric intractable epilepsy.Methods Using the ELISA method to detect the changes of IL-6 content in 48 cases of pediatric intractable epilepsy seizures in the serum and cerebrospinal fluid.Results The IL-6 level in serum was 8.23±0.58 pg/ml and 11.63±1.35 pg/ml in 1 h and 6 h after seizure,respectively,which was significantly different with controls(0.75±0.48 pg/ml,1 h: P<0.05;6 h: P<0.01).In addition,The IL-6 level in serum was 10.35±3.06 pg/ml and 19.55±2.32 pg/ml in 1 h and 6 h after seizure,respectively,which was also significantly increased compared with controls(1.27±0.65 pg/ml,P<0.01).However,the IL-6 levels in serum and CSF 12 h after seizure were tendency towards the baseline.Conclusion The seizure induced an increase of IL-6 levels in serum and CSF,which may exacerbate the injury caused by inflammation,would be involved in the epileptogenesis of pediatric intractable epilepsy.