颅脑手术后颅内感染危险因素及用药途径的探讨

目的 探讨颅脑手术后颅内感染的危险因素及治疗方法.方法 对1 446例颅脑手术后48例发生颅内感染的患者进行了回顾性分析.结果 多种不同的危险因素与颅内感染的发生有关,在择期手术、其他部位手术、全麻手术相比较均有显著性差异(P均＜0.05).结论 急症、后颅凹手术、基础麻醉均为术后发生颅内感染的高危因素, 严格的无菌操作、开展微创手术、围术期使用有效抗生素、针对不同的危险因素采取相应的预防措施可减少术后颅内感染的发生,正确用药对治疗控制颅内感染效果较好.

Risk factors and treatment methods of intracranial infection after craniotomy

Objective To investigate the risk factors and treatment methods of intracranial infection after craniotomy.Methods Of the 1446 patients who underwent craniotomy, 48 patients were complicated by intracranial infection. Data of the 48 patients were analysed retrospectively.Results Many risk factors were associated with intracranial infection after craniotomy. There were significant differences in elective operation, operation on other part of the body and general anesthesia between the two groups (P<0.05).Conclusion Emergent operation, operation at posterior cranial fossa and basal anesthesia are risk factors of postoperative intracranial infection. Strict aseptic technique, minimally invasive surgery,use of effective antibiotics in periopertive period and corresponding preventive measures can reduce the incidence of intracranial infection after surgery. Using correct antibiotics in the treatment of intracranial infection can improve the therapeutic results.