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Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis
Authors:Elizabeth T. Jensen  Jonathan T. Kuhl  Lisa J. Martin  Carl D. Langefeld  Evan S. Dellon  Marc E. Rothenberg
Affiliation:1. Department of Epidemiology and Prevention, Wake Forest University Public Health Sciences, Winston-Salem, NC;6. Department of Biostatistical Sciences, Wake Forest University Public Health Sciences, Winston-Salem, NC;2. Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC;g. Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC;3. Division of Allergy and Immunology, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;5. Division of Human Genetics, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;4. Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio
Abstract:
Keywords:Early-life factors  eosinophilic esophagitis  gene-environment interaction  exposures  aOR  Adjusted odds ratio  EoE  Eosinophilic esophagitis  NICU  Neonatal intensive care unit  RERI  Relative excess risk due to interaction  SNP  Single-nucleotide polymorphism
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