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Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps |
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| Authors: | Heng Wang Danh C. Do Jinxin Liu Baofeng Wang Jingjing Qu Xia Ke Xiaoyan Luo Ho Man Tang Ho Lam Tang Chengping Hu Mark E. Anderson Zheng Liu Peisong Gao |
| Affiliation: | 1. Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Md;2. Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;3. Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China;4. Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Md;5. Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md;6. Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Md |
| Abstract: | |
| Keywords: | Chronic rhinosinusitis with nasal polyps aryl hydrocarbon receptor (AhR) kynurenine mast cell calmodulin-dependent protein kinase II (CaMKII) AhR Aryl hydrocarbon receptor BMMCs Bone marrow–derived mast cells CaMKII Calmodulin-dependent protein kinase II CRS Chronic rhinosinusitis CRSwNP Chronic rhinosinusitis with nasal polyps Cyp1a1 Cytochrome P450 family 1 subfamily A member 1 Cyp1b1 Cytochrome P450 family 1 subfamily B member IDO1 Indoleamine 2,3-dioxygenase 1 KYN Kynurenine NP Nasal polyp OVA Ovalbumin Ox-CaMKII Oxidized calmodulin-dependent protein kinase II PCA Passive cutaneous anaphylaxis ROS Reactive oxygen species TDO2 Tryptophan2,3-dioxygenase WT Wild-type |
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