Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia |
| |
| Authors: | Jankovic J Hunter C Dolimbek B Z Dolimbek G S Adler C H Brashear A Comella C L Gordon M Riley D E Sethi K Singer C Stacy M Tarsy D Atassi M Z |
| |
| Affiliation: | Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, USA. josephj@bcm.tmc.edu |
| |
| Abstract: | In this multicenter study of 100 patients with cervical dystonia, we examined the immunogenicity of botulinum toxin type B (BTX-B) and correlated the clinical response with the presence of blocking antibodies (Abs) using a novel mouse protection assay. One-third of the patients who were negative for BTX-B Abs at baseline became positive for BTX-B Abs at last visit. Thus, the high antigenicity of BTX-B limits its long-term efficacy. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
