氯氮平与利培酮对血清脂联素的影响

目的：研究氯氮平与利培酮对血清脂联素（Adi）等代谢的影响。方法：69例精神分裂症患者随机分为氯氮平组和利培酮组。治疗6周测定患者血清Adi，血脂，空腹血糖、胰岛素水平，计算胰岛素抵抗指数（IR），测量身高、体质量，计算体质量指数（BMI），并与36名正常对照者比较。结果：两患者组治疗后的血清Adi明显降低，氯氮平组血清Adi改变与BMI相关；利培酮组血清Adi改变与IR和利培酮剂量相关。结论：氯氮平与利培酮治疗精神分裂症患者可引起血清Adi降低，并与体质量增加、IR、血脂及利培酮剂量密切相关。

The effects of clozapine and risperidone on serum adiponectin

Objective:To explore the effect of clozapine and risperidone on adiponectin(Adi) and other mblism in schizophrenic patients. Method:69 schizophrenic patients were randomly divided into clozapine group and risperidone group.Before and after six-week treatment,Adi cholesterol,fasting blood glucose and insulin were measured respectively,insulin resistance(IR) was then calculated.The height,body weight were measured and body mass index (BMI) was then caculated.36 healthy persons were recruited as normal control. Results:After treatment,the serum Adi in both patient groups significantly decreased.The serum Adi level was significantly correlated with BMI in clozapine group.The serum Adi level in risperidone group was correlated with IR and the dose of risperidone. Conclusion:The serum Adi level decrease is significantly correlated with body weight gain,IR and cholesterol levels,the dose of risperidone after clozapine or risperidone treatment.