Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency |
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| Authors: | D. A. Fulcher D. T. Avery N. L. Fewings L. J. Berglund S. Wong D. S. Riminton S. Adelstein S. G. Tangye |
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| Affiliation: | 1. Immunology Unit, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead,;2. Garvan Institute of Medical Research,;3. Centenary Institute of Cancer Medicine and Cell Biology,;4. Concord Hospital, and;5. Royal Prince Alfred Hospital, Sydney, NSW, Australia |
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| Abstract: | Common variable immunodeficiency (CVID) is a B cell immunodeficiency disorder characterized frequently by failure of memory B cell development and antibody secretion. A unifying cellular pathogenesis for CVID has not been forthcoming, but given the immunoregulatory role of invariant NK (iNK) T cells and their absence in several other immunodeficiencies, we quantified these cells in the blood of 58 CVID patients. There was a marked decrease in the proportion of iNK T cells in CVID patients compared with controls. This was particularly notable in those with low isotype‐switched memory B cells, but subset analysis demonstrated no difference when stratified by specific clinical features. We propose that the decreased proportion of iNK T cells in CVID might be linked to the failure of memory B cell generation, which may contribute to reduced antibody production in these patients. |
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| Keywords: | B cells common variable immunodeficiency NK T cells |
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