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Role of musculoskeletal ultrasonography in the detection of subclinical synovitis in oligo and polyarticular juvenile idiopathic arthritis children
Authors:Hanaa S. El-Banna  Doaa W. Nada  Manal S. Hussein  Shymaa A. Hablas  Nivine F. Darwish  Mohammed H. Abu-Zaid  Suzan E. Gadou
Affiliation:Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Tanta University, Egypt
Abstract:

Aim of the work

To study the ability of ultrasound to detect subclinical synovitis in children with oligoarticular and polyarticular juvenile idiopathic arthritis (JIA) and to assess the disease activity according to the clinical, laboratory, and musculoskeletal ultrasonographic (MSUS) evaluation.

Patients and methods

The study included 40 children with oligoarticular or polyarticular JIA diagnosed according to the ILAR criteria. 800 joints (20 joints for each patient: knees, wrists, 2nd–5th metacarpophalangeal and 2nd–5th proximal interphalangeal joints) were subjected to MSUS scanning for synovial hypertrophy, joint effusion and power Doppler (PD) signals. Disease activity assessment using Juvenile Arthritis Disease Activity Score (JADAS-10), and functional assessment By Childhood Health Assessment Questionnaire (CHAQ) were done for all patients.

Results

The mean age of patients was 10.3?±?3.9 (3–16)?years, 24 females and 16 males and the disease duration was 3.7?±?2.8 (0.5–12)?years. There was a significant difference between number of clinically (n?=?192; 24%) and MSUS (440 by gray scale and 240 by PD) affected joints (p?

Conclusion

MSUS is superior to clinical examination in early detection of synovitis. It is a reliable method for disease activity assessment in JIA patients, so it can be used in association with standard clinical examination for better classification, diagnosis, treatment strategy and prognosis of JIA subtypes.
Keywords:Juvenile idiopathic arthritis  Musculoskeletal ultrasonography  Juvenile Arthritis Disease Activity Score  Childhood health assessment questionnaire
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