| Wnt信号系统对骨髓间充质干细胞向心肌细胞分化的作用 |
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| 引用本文： | 江志羔,黄裕立,麦炜颐. Wnt信号系统对骨髓间充质干细胞向心肌细胞分化的作用[J]. 国外医学:内科学分册, 2009, 36(11): 628-631,642 |
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| 作者姓名： | 江志羔 黄裕立 麦炜颐 |
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| 作者单位： | 中山大学附属第一医院心血管内科,广东广州,510080;南方医科大学附属顺德第一人民医院心内科,广东顺德,528300 |
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| 基金项目： | 广东省卫生厅基金,广东省自然科学基金 |
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| 摘 要： | 骨髓间充质干细胞（BMSCs）移植治疗冠状动脉粥样硬化性心脏病、慢性心力衰竭等已经成为心脏病治疗学的热门课题,但细胞疗法依赖于干细胞向心肌细胞的定向分化,目前对BMSCs分化为心肌细胞的分子机制了解不多。Wnt信号系统与器官的分化和形成密切相关,大量研究表明,Wnt信号系统对干细胞向心肌细胞的定向分化有重要作用,对该信号系统的控制,在心脏病的细胞疗法中显得尤其重要。本文将就Wnt信号系统在BMSCs的增殖、迁移及心肌定向分化中的调控作用展开论述。
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| 关 键 词： | Wnt信号 骨髓间允质干细胞 心肌细胞分化 |
Affects of Wnt signaling pathway in differentiation of bone marrow mesenchymal stem cells into cardiomyocytes |
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| JIANG Zhi-gao,HUANG Yu-li,MAI Wei-yi. Affects of Wnt signaling pathway in differentiation of bone marrow mesenchymal stem cells into cardiomyocytes[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(11): 628-631,642 |
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| Authors: | JIANG Zhi-gao HUANG Yu-li MAI Wei-yi |
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| Affiliation: | JIANG Zhi-gao1,HUANG Yu-li2,MAI Wei-yi1.1 Department of Cardiology,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China,2 Department of Cardiology,the Shunde Affiliated Hospital,Southern Medical University,Shunde 523800 |
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| Abstract: | It is focused to treat heart diseases such as coronary heart disease and chronic heart failure with bone marrow mesenchymal stem cells(BMSCs) transplantation. A common feature of these heart diseases is lost of cardiomyocytes,so cell therapy,which depends on cardiomyocytes differentiation,is the most perspective method. However,the molecular signals in cardiomyocytes differentiation are not fully understood. A big deal data indicated that Wnt signaling regulating the differentiation and morphogenesis of org... |
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| Keywords: | Wnt signaling Bone marrow mesenchymal stem cells Cardiomyocyte differentiation |
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