Evidence that neurofibrillary tangles undergo glial modification |
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| Authors: | K Ikeda H Akiyama C Haga S Haga |
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| Institution: | (1) Tokyo Institute of Psychiatry (previous Psychiatric Research Institute of Tokyo), Department of Neuropathology, 2-1-8, Kamikitazawa, Setagaya-ku, 156 Tokyo, Japan;(2) Tokyo Institute of Psychiatry (previous Psychiatric Research Institute of Tokyo), Department of Ultrastructure, 2-1-8, Kamikitazawa, Setagaya-ku, 156 Tokyo, Japan |
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| Abstract: | Summary Ghost tangles, neurofibrillary tangles (NFTs) emerging into extracellular space, appear to be subjected to some microglial association in addition to an invasion of astrocytic processes. Our findings lead us to speculate that the NFTs undergo structural and immunocytochemical modification. Electron microscopic observation of the NFTs in the vascular region indicated either the discharge of NFTs into the vessel or formation of NFTs in the astrocytic end-foot. |
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| Keywords: | Alzheimer-type dementia Ghost tangle Microglia Astrocyte |
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