| 定性和定量观察吸烟引起肺肌型动脉中膜的形态学改变 |
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| 引用本文： | 何建芳,廖松林,孟繁农,关迺源,郭海恩,徐昆. 定性和定量观察吸烟引起肺肌型动脉中膜的形态学改变[J]. 北京大学学报(医学版), 1992, 0(5) |
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| 作者姓名： | 何建芳 廖松林 孟繁农 关迺源 郭海恩 徐昆 |
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| 作者单位： | 北京医科大学病理学教研室(何建芳，廖松林，孟繁农)，中国预防医学科学院环境卫生与预防工程研究所(关迺源，郭海恩)，中国预防医学科学院环境卫生与预防工程研究所(徐昆) |
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| 摘 要： | 以同月龄组大鼠作主动性吸烟实验,应用光镜、电镜、图象分析仪及形态测量学技术等,观察了吸烟引起肺肌型动脉(MPA)中膜的形态学改变。结果表明:中膜明显增厚,平滑肌细胞(SMC)增生肥大、形态变异,与合成功能有关的细胞器增多,并向内膜迁移,细胞外纤维组织和基质增多。虽然这些病变的功能意义尚不清楚,但其在吸烟所致的肺动脉高压和肺心病的发生和发展中可能起重要作用。
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| 关 键 词： | 吸烟 肺动脉 平滑肌细胞 形态测量 |
QUALITATIVE AND QUANTITATIVE OBSERVATIONS OF SMOKING-INDUCED MORPHOLOGIC CHANGES IN MEDIA OF MUSCULAR PULMONARY ARTERIES |
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| He Jianfang. QUALITATIVE AND QUANTITATIVE OBSERVATIONS OF SMOKING-INDUCED MORPHOLOGIC CHANGES IN MEDIA OF MUSCULAR PULMONARY ARTERIES[J]. Journal of Peking University. Health sciences, 1992, 0(5) |
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| Authors: | He Jianfang |
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| Affiliation: | He Jianfang Department of Pathology |
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| Abstract: | Light microscopy, transmission electron microscopy, image processing and morphometric techniquewere applied to analyze the morphologic changes in the media of muscular pulmonary arteries fromthe rats after exposure to smoking, The results showed significant thickening of the media, proliferationof the smooth muscle cells and their migration from the media to intima of artery, modification ofthe cell shape and increase of rough endoplasmic reticulium, and significant increase of extracellularfibroplasia and matrix. Although the functional significance of these findings is unknown, they mightplay an important role in the occurence and development of smoke-induced pulmonary hypertensionand cor pulmonale. |
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| Keywords: | Smoking Pulmonary artery Smooth muscle cell Morphometry |
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