简化估算肾小球滤过率模型算法的参考限及临床特性

目的调查不同估算肾小球滤过率(eGFR)公式的参考范围及其临床应用特性。方法测定健康人群血清肌酐(苦味酸法、酶法)及半胱氨酸蛋白酶抑制剂C(Cys C),统计参考限。把肌酐及Cys C测定值代入不同的eGRF公式(美国2个、中国3个、日本3个、Cys C 4个),统计其95%可信区间(CI)。测定83例肾功能异常患者(男43例、女40例)血清肌酐及Cys C,代入不同的eGRF公式,以相关分析观察其一致性。改变某一变量(测定浓度、年龄和干扰),考核对eGFR模型的影响程度。综合归纳eGFR方法适用范围。结果肌酐苦味酸法95%CI男、女分别为73~120、55~97μmol/L;酶法分别为34~106、18~75μmol/L;Cys C为0.38~0.98 mg/L。肌酐苦味酸法、酶法99%CI分别为41~132、26~120μmol/L。全国推荐法、美国法、美国IDMS法、瑞金医院、中山医院、日本推荐法、日本苦味酸法、日本酶法、Cys C66.8、Cys C91.6、Cys C77.24、Cys C中山医院eGFR 95%CI分别为53~123、49~110、48~227、52~110、38~85、36~85...

Reference interval and clinical characteristic of simplified eGFR models

Objective To investigate the reference interval of different estimated glomerular filtration rate(eGFR) models and their clinical characteristics.Methods The concentrations of serum creatinine(Jaffe kinetic creatinine assay and enzymic method) and cystatin C(Cys C) were determined and the reference intervals were analyzed statistically in healthy subjects(eGFR algorithms:2 in American,3 in Chinese,3 in Japanese and 4 in Cys C).The 95% confidence interval(CI) was analyzed statistically.The creatinine and Cys...