壮骨止痛方提取物对去势雌鼠骨密度和骨生物力学影响

目的:观察壮骨止痛方对双侧卵巢摘除(去势法)后雌性大鼠骨密度及骨生物力学的影响。方法:60只雌性SD大鼠随机分为空白组、假手术组、模型组、壮骨止痛方全方组,每组15只。术后1 w开始灌胃给药,连续13 w。13 w后按要求处死动物,观察雌性大鼠去势后骨质疏松模型骨密度及左后肢胫骨生物力学的变化。结果:壮骨止痛方能增加大鼠骨密度、胫骨最大应力和最大抗弯强度,与模型组比较差异有统计学意义。结论:壮骨止痛方具有抗骨质疏松的作用。

Effects of extracts from Zhuanggu Zhitong formula on expression of bone density and bone biomechanics in ovariectomized rats

Objective：To observe effect of extracts from Zhuanggu Zhitong formula on bone mineral density and bone biome-chanics of female rats with bilateral ovaries resection （ovariectomy）. Methods：60 female SD rats were randomly separated into blank group,sham-operated group,model group and Zhuanggu Zhitong formula group with 15 rats in each group. Cas-trated female rats model were made by ovariectomy,then were killed after 13 weeks′ feeding. Finally,the changes of bone mineral density and bone biomechanics of castrated female rats were observed. Results：Zhuanggu Zhitong formula could increased the bone density,maximum stress of shin bone and the maximum flexural strength of the rats,which had sig-nificant differences comparing with model group（P〈0.05）. Conclusion：Zhuanggu Zhitong formula possess anti-osteoporo-sis effect.