胃癌术后中医证素分布及组合规律的文献分析

目的:基于近15年文献报道探讨胃癌术后中医证素分布与组合规律。方法:通过计算机检索CNKI、万方数据库和维普数据库,对近15年胃癌术后文献进行筛选整理,对其证素的分布和组合规律进行分析。结果:13个证素中,气虚频率最高(36.01%),其次为血虚(9.44%)、阳虚(8.74%)、气滞(7.69%)、阴虚(7.69%)等;作用靶点主要位于胃(37.18%),其次为脾(35.38%)、肝(9.03%)等。单一病性证素构成的证候有血虚证、阳虚证、阴虚证、气滞证、血瘀证等,累积频率8.24%。两病性证素的组合主要有气虚+血虚、阴虚+血虚、血虚+血瘀、气滞+血瘀、湿+热等,累积频率4.39%。单一病性证素与单一靶点组合,靶点以胃、肾为主,病性证素有气虚、气滞、阳虚、阴虚,表现为肾气虚、胃气滞、胃阳虚、胃阴虚,累积频率为83.52%。三证素构成的证候主要为两病性证素+单一作用靶点构成,组合有脾阳气虚证、胃气阴两虚证,累积频率为3.85%。结论:胃癌术后患者以气虚、血虚、阴虚、阳虚等为本,气滞、血瘀、湿热等为标。

Literature analysis on distribution and combination rules of TCM syndrome elements of postoperative gastric cancer

Objective：To study distribution and combination rules of TCM syndrome elements of postoperative gastric can-cer based on recent 15 years literatures. Method：Literatures about postoperative gastric cancer in CNKI,Wanfang and VIP databases in recent 15 years were searched and screened by computer,then distribution and combination rules of syndrome elements were analyzed. Results：The highest frequency in 13 syndrome elements was qi deficiency （36.01%）,followed by blood deficiency（9.44%）,yang deficiency（8.74%）,qi stagnation（7.69%）and yin deficiency（7.69%）. The target was mainly located in the stomach（37.18%）,followed by the spleen（35.38%）,liver（9.03%）. Combination of two syndrome elements concluded qi deficiency and blood deficiency,yin deficiency and blood deficiency,blood deficiency and blood stasis,qi stagnation and blood stasis,wet and heat,etc. Combination of single syndrome element and single target concluded qi defi-ciency of kidney,qi stagnation of stomach,yang deficiency of stomach and yin deficiency of stomach. Combination of two syndrome elements and single target concluded yang deficiency and qi deficiency of spleen,qi deficiency and yin deficien-cy of stomach. Conclusion：About pathogenesis of postoperative gastric cancer,qi deficiency,blood deficiency,yin defi-ciency and yang deficiency were origin,while qi stagnation,blood stasis,wet and heat are branches.