2型糖尿病尿5种蛋白联合检测的临床意义

目的 :了解 2型糖尿病尿 5种蛋白变化的临床意义。方法 :对 2 0 4例 2型糖尿病患者和 44例正常对照者(C组 )同时进行 2 4h尿Alb、Trf、IgG、RBP、NAG(分别简称UAE、UTE、UIE、URBPE及UNAGE)、尿糖排泄 (UGE)和肌酐清除率 (Ccr)的检测。根据 2 4hUAE分为 3组 :正常白蛋白尿组 (Ⅰ组 ) ;微量白蛋白尿组 (Ⅱ组 )及大量白蛋白尿组(Ⅲ组 )。结果 :(1) 2 0 4例中 ,微量和大量白蛋白尿发生率为 41 2 %和 7 8% ,与C组相比 ,Ⅱ组Ccr略降低 (P >0 0 5 ) ,Ⅲ组Ccr明显降低 (P <0 0 5 ) ;(2 )UTE在 3组患者中均与UAE呈显著相关 ;UIE在Ⅲ组与UAE明显相关 ;UNAGE在Ⅱ组与UAE明显相关 ;(3)URBPE增高的发生率在Ⅰ组、Ⅱ组和Ⅲ组分别为 11 5 %、42 9%和 75 %。结论 :不同分子量尿多种蛋白联合检测对糖尿病肾脏病变的早期发现和定位有较大的价值

Clinical significance of combined measurements of urinary five proteins in type 2 diabetic patients

Objectiv:To assess the clinical significance of urinary five proteins change in type 2 diabetics.Methods:24 hour urinary albumin、transferrin、IgG、retinol-bingding protein,N-acetyl-glucosaminidase,glucose excretion (named UAE,UTE,UIE,URBPE,UNAGE and UGE) and creatinine clerance rate (Ccr) were measured and analysed in 204 type 2 diabetic patients and 44 control subjects (group C). 204 patients were divided into three groups according their 24h UAE:Group Ⅰ (normoalbuminuria),group Ⅱ (microalbuminuria) and group Ⅲ (macroalbuminuria).Results:(1) The prevalence rates of micro-and macroalbuminuria were 41.7% and 7.8% among 204 patients.Compared with group C,the Ccr decreased sligtly in group Ⅱ (P>0.05),but decreased significantly in group Ⅲ (P<0 05);(2) UTE (in all three groups),UIE(in group Ⅲ) and UNAGE (in group Ⅱ) had significant positive relationship with UAE;(3) The raised prevalence rates of URBPE were 11.5%、42.5% and 75.0%,respectively among group Ⅰ,group Ⅱ and group Ⅲ.Conclusion:Urinary five proteins combination measurement had more importmant value for the early diagnosis and localization of diabetic kidney disease.