| Caveolin-1在食管鳞癌中的表达及其临床意义 |
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| 引用本文： | 葛腾飞,朱克超,于在诚,汪渊. Caveolin-1在食管鳞癌中的表达及其临床意义[J]. 安徽医科大学学报, 2012, 47(5): 544-547 |
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| 作者姓名： | 葛腾飞 朱克超 于在诚 汪渊 |
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| 作者单位： | 安徽医科大学第一附属医院胸外科,合肥,230022;安徽医科大学分子生物学实验室,省部共建重要遗传病基因资源利用重点实验室,合肥,230032 |
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| 基金项目： | ,国家自然科学基金,安徽省科技厅重点科研项目 |
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| 摘 要： | 目的探讨Caveolin-1蛋白在食管鳞癌中的表达及其临床意义。方法应用免疫组化法和免疫印迹法检测65例食管鳞癌患者的癌组织及对应癌旁正常食管黏膜中Cave-olin-1的表达情况。结果食管鳞癌组织中Caveolin-1蛋白的表达水平高于对应癌旁正常食管黏膜,差异有统计学意义(P<0.05),食管鳞癌组织中Caveolin-1蛋白的表达水平与其分化程度相关(P<0.05),与淋巴结转移、TNM分期等无关。结论 Caveolin-1蛋白在食管鳞癌中的高表达可能与其发生发展有关。
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| 关 键 词： | 食管肿瘤 鳞状细胞 免疫组织化学 免疫印迹法 Caveolin-1 |
Expression and clinical significance of Caveolin-1 in esophageal squamous cell carcinoma |
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| Affiliation: | Ge Tengfei,Zhu Kechao,Yu Zaicheng,et al(Dept of Thoracic Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Objective To investigate the expression and clinic characteristics of Caveolin-1 in esophageal squamous cell carcinoma(ESCC).Methods Expression of Caveolin-1 in 65 patients of ESCC and normal esophageal epithelial tissue were detected by immunohistochemistry and Western blot analysis.Results The expression level of Caveolin-1 was significantly higher in ESCC than that in the normal esophageal epithelial tissue(P < 0.01),and up-regulation of Caveolin-1 was correlated with differentiation of ESCC.It had no relationship with lymph node metastasis or TNM stage.Conclusion The overexpression of Caveolin-1 may play an important role in the progression of human ESCC. |
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| Keywords: | esophageal neoplasms squamous cell immunohistochemistry Western blot Caveolin-1 |
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