| 基质金属蛋白酶-9在脑缺血过程中的双重作用 |
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| 引用本文： | 李春艳,吉训明,朱榆红,罗玉敏.基质金属蛋白酶-9在脑缺血过程中的双重作用[J].国际脑血管病杂志,2007,15(9):703-706. |
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| 作者姓名： | 李春艳 吉训明 朱榆红 罗玉敏 |
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| 作者单位： | 首都医科大学宣武医院脑血管病研究所,北京,100053 |
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| 基金项目： | 国家自然科学基金(NO.30670725) |
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| 摘 要： | 基质金属蛋白酶-9(MMP-9)是MMP家庭中的一员,可特异性降解细胞外基质。脑缺血早期(1～3d),MMP-9可通过降解基底膜及内皮细胞紧密连接破坏血脑屏障,导致继发性脑水肿和脑出血。脑缺血后期(7～14d),MMP-9则能促进神经血管再生,有利于损伤脑组织的恢复。
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| 关 键 词： | 基质金属蛋白酶-9 脑缺血 血脑屏障 |
| 收稿时间： | 2007-06-15 |
| 修稿时间： | 2007-08-07 |
The Double Roles of Matrix Metalloproteinase-9 in Cerebral Ischemia |
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| Chun-Yan Li,Xun-Ming Ji,Yu-Hong Zhu,Yu-Min Luo.The Double Roles of Matrix Metalloproteinase-9 in Cerebral Ischemia[J].International Journal of Cerebrovascular Diseases,2007,15(9):703-706. |
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| Authors: | Chun-Yan Li Xun-Ming Ji Yu-Hong Zhu Yu-Min Luo |
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| Institution: | Cerebrovascular Diseases Institute, Xuanwu Hospital, Capitd University of Medicd Sciences, Beijing 100053, China |
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| Abstract: | Matrix metalloproteinase-9 (MMP-9), a member of MMP family, can specifically degrade extracellular matrix. During the early stage of cerebral ischemia (1-3 days), MMP-9 disrupts blood-brain barrier by degrading basal lamina and endothelial tight junction resulting in secondary brain edema and intracerebral hemorrhage. During the late stage of cerebral ischemia (7-14 days), MMP-9 may promote neurovascular regeneration, and it is beneficial for the recovery of the damaged brain tissues. |
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| Keywords: | matrix metalloproteinase-9 cerebral ischemia blood-brain barrier |
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