| 胃泌素释放肽受体在鳞状细胞癌中的检测及临床意义 |
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| 引用本文： | 王建军,张晓鸣,张军,翟学锋,尚元元. 胃泌素释放肽受体在鳞状细胞癌中的检测及临床意义[J]. 中国皮肤性病学杂志, 2011, 25(5) |
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| 作者姓名： | 王建军 张晓鸣 张军 翟学锋 尚元元 |
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| 作者单位： | 1. 宁夏医科大学附属医院皮肤科,宁夏,银川,750004
2. 宁夏医科大学附属医院病理科,宁夏,银川,750004 |
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| 摘 要： | 目的检测鳞状细胞癌(squamous cell carcinoma,SCC)中的胃泌素释放肽受体(gastrin releasing peptide receptor,GRPR)探讨其与SCC分化程度的关系。方法用免疫组化(SP)法检测10例正常皮肤组织及46例不同分化程度SCC中GRPR的表达。结果 SCC组中33例(71.74%)阳性表达,正常皮肤组织中3例(30.00%)阳性表达,两组间GRPR的表达差异有统计学意义(P=0.022);高、中、低分化组中阳性表达分别为14例(70.00%)、9例(75.00%)、10例(71.43%),不同分化程度SCC组间GRPR的表达差异无统计学意义(P=0.916)。结论 GRPR在SCC及正常皮肤中均有表达,但在SCC中的表达高于正常皮肤,其表达与SCC的侵袭性无相关性。
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| 关 键 词： | 胃泌素释放肽受体 鳞状细胞癌 免疫组化 |
Detection of GRPR in Squamous Cell Carcinoma |
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| WANG Jian-jun,ZHANG Xiao-ming,ZHANG Jun,ZHAI Xue-feng,SHANG Yuan-yuan. Detection of GRPR in Squamous Cell Carcinoma[J]. The Chinese Journal of Dermatovenereology, 2011, 25(5) |
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| Authors: | WANG Jian-jun ZHANG Xiao-ming ZHANG Jun ZHAI Xue-feng SHANG Yuan-yuan |
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| Affiliation: | WANG Jian-jun1,ZHANG Xiao-ming1,ZHANG Jun2,ZHAI Xue-feng2,SHANG Yuan-yuan1(1.Department of Dermatology,Affiliated Hospital of Ningxia Medical University,Yinchuan 750004,China,2.Department of Pathology,China) |
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| Abstract: | Objective To investigate the expression of GRPR(gastrin-releasing peptide recepter) in different grade of squamous cell carcinoma.Methods The expression of GRPR in 10 normal skin specimens and 46 SCC specimens was detected by immunohistochemistry(SP method).Results Thirty three(71.74%)of SCC specimens and 3(30.00%)of normal skin showed positive expression with significant differences(P=0.022).Of all positive SCC,14(70.00%)were in well-differentiated group,9(75.00%)in moderately-differentiated group,and 10(7... |
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| Keywords: | GRPR Squamous cell carcinoma Immunohistochemistry |
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