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Iatrogenic epithelial change caused by endotracheal intubation of neonates
Authors:G S Gau  T A Ryder  M A Mobberley
Affiliation:1. Service épilepsie, sommeil et explorations fonctionnelles neuropédiatriques, centre de recherche en neurosciences de Lyon (CRNL), hôpital Femme-Mère-Enfant, hospices civils de Lyon (HCL) et Inserm U1028, CNRS UMR5292, 59, boulevard Pinel, 60700 Lyon, France;2. SHW Health Limited, 40, Lena-Gardens, Londres W6 7PZ, Royaume-Uni;3. Inserm, U676, service de neurologie pédiatrique, hôpital Robert-Debré, AP–HP, 75019 Paris, France;4. Service de neurologie pédiatrique, université Paris Descartes et Inserm U781, Imagine, université Paris Descartes, hôpital Necker Enfants Malades, AP–HP, 75015 Paris, France;5. CHU d’Angers, 4, rue Larrey, 49933 Angers, France;1. Service de spécialités pédiatriques et médecine infantile, CHU Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France;2. Urgences pédiatriques, CHU Timone Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France;3. Laboratoire de santé publique, faculté de médecine, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France;4. Réanimation et urgences pédiatriques, hôpital Mère-Enfant, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France;5. Service de pédiatrie, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France;1. Columbia University College of Physicians and Surgeons, New York, NY, USA;2. NewYork–Presbyterian Morgan Stanley Children''s Hospital, New York, NY, USA;1. Service de réanimation néonatale et pédiatrique, CHU d’Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France;2. Université Pierre et Marie Curie (UPMC), 75005 Paris, France;3. Unité Inserm U1141, hôpital Robert-Debré, 75019 Paris, France;1. Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, CA, United States;2. Clinical Excellence Research Center, Department of Medicine, Stanford University, Stanford, CA, United States;3. Department of Emergency Medicine, Stanford University, Stanford, CA, United States;4. Department of Surgery, Palo Alto Veterans Affairs, Palo Alto, CA, United States;1. École de sage-femme, université de Brest, 29200 Brest, France;2. Faculté de médecine et des sciences de la santé, EA 4686, université de Brest, 29200 Brest, France;3. Université européenne de Bretagne, 29200 Brest, France;4. Pôle de la femme, de la mère et de l’enfant, CHU de Brest, 29220 Brest, France
Abstract:
Tracheae of 20 neonates were obtained at postmortem examination. All neonates had been intubated for between 4 h and 105 days. The tracheal epithelial lining was examined by both light and scanning electron microscopy. Five tracheae which had never been intubated served as controls. All of these showed ciliation throughout their length. Those neonates who had been intubated showed epithelial change which ranged from a simple deciliation to a full stratified squamous epithelium. The degree of change was broadly related to the duration of intubation.
Keywords:
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