| Effects of isolation housing and timing of drug administration on amikacin kinetics in mice |
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| 引用本文： | 周瑞海,堤喜美子,中野重行. Effects of isolation housing and timing of drug administration on amikacin kinetics in mice[J]. Acta pharmacologica Sinica, 1997, 0(4) |
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| 作者姓名： | 周瑞海 堤喜美子 中野重行 |
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| 作者单位： | 大分医科大学临床药理与治疗学科 |
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| 摘 要： | 目的：研究社会环境及给药时刻对小鼠阿米卡星代谢的影响．方法：小鼠按饲养环境：隔离饲养（Ｉ）或集体饲养（Ａ）及给药时间：日中（Ｄ）及午夜（Ｎ）随机分为：Ｉ－Ｄ，Ｉ－Ｎ，Ａ－Ｄ，Ａ－Ｎ４组．饲养４周后于Ｄ（１３∶００）或Ｎ（０１∶００）ｓｃ阿米卡星１５ｍｇ·ｋｇ－１，测定给药后其血浆浓度，以开放一室模型拟合并计算有关药代动力学参数．结果：Ａ－Ｎ组阿米卡星清除率较Ａ－Ｄ及Ｉ－Ｎ组增大，血浆半衰期变短，０－１小时血浆浓度时间曲线下面积（ＡＵＣ（０－１））较Ｉ－Ｎ组减少．隔离饲养两组（Ｉ－Ｄ，Ｉ－Ｎ）间药代动力学参数无显著差异．结论：社会环境及给药时刻均显著影响小鼠阿米卡星代谢动力学．
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| 关 键 词： | 社会隔绝；动物住房；给药计划表；阿米卡星；时间生物学；药物动力学 |
Effects of isolation housing and timing of drug administration on amikacin kinetics in mice |
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| ZHOU Rui Hai ,TSUTSUMI Kimiko,NAKANO Shigeyuki. Effects of isolation housing and timing of drug administration on amikacin kinetics in mice[J]. Acta pharmacologica Sinica, 1997, 0(4) |
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| Authors: | ZHOU Rui Hai TSUTSUMI Kimiko NAKANO Shigeyuki |
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| Affiliation: | ZHOU Rui Hai 1,TSUTSUMI Kimiko,NAKANO Shigeyuki |
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| Abstract: | |
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| Keywords: | social isolation animal housing drug administration schedule amikacin chrono-biology pharmacokinetics |
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