急性心肌梗死患者炎性细胞因子水平测定

目的通过比较急性心肌梗死（AMI）患者和正常人群血液中细胞因子肿瘤坏死因子-α（TNF-α）、白介素-1（IL-1）、白介素-6（IL-6）]的含量，探讨其在AMI的发生和发展中的作用。方法选择AMI患者56例，健康对照组55名作对比研究。应用放射免疫分析法测定血浆中3种细胞因子（TNF-α、IL-1、IL-6）的含量。结果两组比较，AMI组血液中TNF-α（0．81±0．39）ng／ml]及IL—1β（0．30±0．14）ng／ml]水平明显高于健康对照组血液中TNF-α（0．61±0．22）ng／ml]及IL—1β（0．22±0．11）ng／ml]水平（P〈0．01），IL-6含量两组差异无统计学意义。结论炎性细胞因子在AMI过程当中起一定的作用，炎症反应的激活可能是导致斑块不稳定的重要因素。

Significiance of blood level of inflammatory cytokines in acute myocardial infarction patients

Objective To compare the inflammatory eytokines（TNF-α,IL-1 ,IL-6） in the blood between AMI patients and health adult , and investigate its effect in the AMI developing. Methods We choice 56 AMI patients as the AMI group,55 health adult as the normal control. To measure the inflammatory eytokines （TNF-α, IL-1 ,IL-6） in the blood of these two groups by radio immunoassay. Results The level of TNF-α and IL-1β in the AMI group is obviously higher than that of normal control （P〈0.01）.There were no signifieiant diferenee of IL- 6 between these two groups. Conclusion Inflammatory eytokines place some degree roles in the AMI progress,inflammatory reaction is an important factor which induce the plaque instable.