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Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2

Authors:	Hong-Hui Li Li-Jun Huo Feng Zhao Zhen-Ya Gao Jun-Wen Zeng

Affiliation:	State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, 54 South Xianlie Road, Guangzhou, 510060, Guangdong Province, China.

Abstract:	Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera, biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.

Keywords:	bone morphogenetic protein-2 sclera myopia

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