鼻咽癌长期生存者的生存质量变化及其影响因素

目的测定鼻咽癌治疗后长期生存者的生存质量变化,并分析其影响因素。方法 1999年～2000年治疗后无瘤生存的90例鼻咽癌患者分别于2003年和2008年接受了生存质量的测定。测定量表包括健康状况调查量表SF-36中文版和包含14个症状的自觉症状评价量表。比较患者两次生存质量的变化,并分析影响生存质量变化的因素。结果同2003年相比,2008年患者SF-36的生理机能领域生存质量变差,而生理职能和精力领域生存质量好转;口干和视力减退症状加重,而味觉减退症状减轻。多因素分析表明,年龄和经济情况是影响患者精力领域生存质量变化的独立因素,生存时间和化疗是影响患者口干症状变化的独立因素。结论鼻咽癌长期生存者的生存质量某些方面存在恶化或好转,但总的生存质量比较稳定,社会人口学和临床因素可能影响生存质量的变化。

The Changes of Quality of Life in Long-term Survivors with Nasopharyngeal Carcinoma and Their Impact Factors

Objective To evaluate the changes of quality of life（QOL） in long-term survivors with nasopharyngeal carcinoma（NPC） after treatment and analyze their impact factors.Methods A total of 90 tumor-free survivors with NPC treated from 1999 to 2000 received the measurement of QOL in 2003 and 2008 respectively.Measurement scales included Chinese SF-36 questionnaire and a checklist consisting of fourteen items about self-rating symptoms.The QOL at the two time points was compared and the factors affecting the changes of QOL were analyzed.Results Compared with those in 2003,in 2008 the physical functioning（PF） domain of SF-36 deteriorated,while the role physical（RP） and vitality（VT） domains improved;the symptoms of dry mouth and dysopia deteriorated,while the symptom of hypogeusia improved.Multivariate analysis showed that age and economic status were independent factors affecting the change of vitality（VT） domain,and survival time and chemotherapy were independent factors affecting the change of dry mouth.Conclusion Some aspects of QOL in long-term survivors with NPC have deterioration or improvement,but the overall QOL is relatively stable,and sociodemographic and clinical factors may affect the changes of QOL.