| 铅毒性的遗传易感性 |
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| 引用本文： | 吴胜虎,颜崇淮,沈晓明. 铅毒性的遗传易感性[J]. 卫生研究, 2004, 33(2): 226-228,232 |
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| 作者姓名： | 吴胜虎 颜崇淮 沈晓明 |
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| 作者单位： | 上海第二医科大学附属新华医院,上海第二医科大学儿童环境医学研究中心,上海市儿科医学研究所,上海200092 |
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| 基金项目： | 国家自然科学基金资助项目(No .39970 645,30 0 70 665)，上海市教委科研基金 (No .97B0 5)，上海市卫生局“百人计划”(No .97BR0 0 9)，上海市优秀学科带头人基金(No.98XD1 4 0 0 5) |
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| 摘 要： | 环境铅污染对儿童健康的影响正日益受到重视。以往的流行病学研究发现 ,机体的易感性可能是铅毒性作用的重要决定因素。δ 氨基 γ 酮戊酸脱水酶基因、维生素D受体基因及血色素沉着病基因等遗传多态性可能造成儿童对铅毒性作用有不同的易感性 ,本文就此进行综述。
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| 关 键 词： | 铅中毒 δ-氨基-γ-酮戊酸脱水酶 维生素D受体 血色素沉着病 基因型 |
| 文章编号： | 1000-8020(2004)02-0226-04 |
Molecular genetic susceptibility to lead poisoning |
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| Wu Shenghu,Yan Chonghuai,Shen Xiaoming Xinhua Hospital,Research Center for Pediatric Environmental Science,Shanghai Second Medical University,Shanghai ,China. Molecular genetic susceptibility to lead poisoning[J]. Journal of hygiene research, 2004, 33(2): 226-228,232 |
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| Authors: | Wu Shenghu Yan Chonghuai Shen Xiaoming Xinhua Hospital Research Center for Pediatric Environmental Science Shanghai Second Medical University Shanghai China |
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| Affiliation: | Xinhua Hospital, Research Center for Pediatric Environmental Science, Shanghai Second Medical University, Shanghai 200092, China. |
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| Abstract: | It was reported that three polymorphic genes were identified to be able to potentially influence the bioaccumulation and toxicokinetics of lead in humans. These genes are delta-aminolevulinic acid dehydratase(ALAD) gene, vitamin D receptor (VDR) and hemochromatosis gene. Their relation to susceptibility to lead poisoning in humans was reviewed in this paper. |
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| Keywords: | lead poisoning δ|aminolevulinic acid dehydratase vitamin D receptor hereditary hemochromatosis |
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