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| MTH1基因在肿瘤发生及治疗中的作用 | |
| 引用本文： | 管叙文,黄鼎智. MTH1基因在肿瘤发生及治疗中的作用[J]. 国际肿瘤学杂志, 2016, 0(1): 26-28. DOI: 10.3760/cma.j.issn.1673-422X.2016.01.007 |
| 作者姓名： | 管叙文 黄鼎智 |
| 作者单位： | 300060,天津医科大学肿瘤医院消化肿瘤内科 国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室 |
| 摘 要： | MTH1蛋白能通过水解氧化的脱氧核糖核苷三磷酸修复活性氧造成的DNA损伤,其在肿瘤细胞中高表达,并维持肿瘤细胞存活.MTH1基因与微小RNA、RAS、p53等肿瘤相关基因关系密切,且MTH1抑制剂可以选择性地抑制肿瘤细胞增殖,是一个极具潜力的肿瘤治疗新靶点. |
| 关 键 词： | 肿瘤 活性氧 靶向治疗 |
Roles of MTH1 gene in the occurrence and treatment of cancers |
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| Abstract: | MTH1 protein can mitigate DNA damage which caused by reactive oxygen species through hydrolyzing oxidized deoxy-ribonucleoside triphosphate.MTH1 is highly expressed in various cancers, so as to maintain the viability of cancer cells.MTH1 is closely related to tumor associated genes such as microRNA,RAS gene and p53 gene.Moreover, MTH1 inhibitors can selectively suppress the proliferation of cancers,which is a potential new target in tumor therapy. |
| Keywords: | Neoplasms Reactive oxygen species Targeted therapy |
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