|
|||||
|
|
| 炎症性肠病基因工程动物模型概述 | |
| 引用本文： | 杨英,CHEN Long-dian. 炎症性肠病基因工程动物模型概述[J]. 国际消化病杂志, 2008, 28(2): 136-139 |
| 作者姓名： | 杨英 CHEN Long-dian |
| 作者单位： | 常州市第一人民医院消化科,213003;南京市鼓楼医院消化科,210008 |
| 摘 要： | 炎症性肠病(IBD)具有遗传异质性,许多免疫调制分子基因的突变可导致炎症发生.转基因和基因敲除动物模型带动了自发性结肠炎动物模型的发展.基因工程动物模型的研究有利于建立新的假说并可能为IBD患者提供新的治疗方法. |
| 关 键 词： | 炎症性肠病 动物模型 转基因模型 基因敲除模型 |
Research of genetically engineered animal models of inflammatory bowel disease |
|
| YANG Ying,CHEN Long-dian. Research of genetically engineered animal models of inflammatory bowel disease[J]. International Journal of Digestive Disease, 2008, 28(2): 136-139 | |
| Authors: | YANG Ying CHEN Long-dian |
| Abstract: | Inflammation arises from a number of mutations of immunomodulatory molecules,supporting the concept of genetic heterogeneity for IBD.Transgenic or knockout of specific genes have led to the development of rodent models of spontaneous colitis.The results obtained from experimental models have generated new hypotheses and suggested novel forms of therapy for IBD patients. |
| Keywords: | Inflammatory bowel disease Animal models Transgenic models Knock-out models |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |