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| 活血化瘀药物在抗Thy-1抗体肾炎中的实验研究 | |
| 引用本文： | 达展云 崔世维 钱桐荪 蒋季杰. 活血化瘀药物在抗Thy-1抗体肾炎中的实验研究[J]. 中国中西医结合肾病杂志, 2000, 1(1): 14-17 |
| 作者姓名： | 达展云 崔世维 钱桐荪 蒋季杰 |
| 作者单位： | 南通医学院附属医院肾内科，南通226001 |
| 基金项目： | 南通市科委资助课题(S9828) |
| 摘 要： | 目的为了探讨活血化瘀中药在抗Thy-1抗体肾炎中的作用及其机理。方法利用大鼠抗Thy一1抗体系膜增殖型肾炎模型，以强的松为对照，研究中药补肾活血汤、保肾康对此模型的干扰。并以免疫组化法，观察。肾组织中增殖细胞核抗原(proliferating cell nuclear antigen，PCNA)的表达。结果实验组大鼠24小时尿蛋白定量、血尿程度、肾脏病理改变及系膜区PCNA阳性细胞数的改变均较模型组明显为轻。结论补肾活血汤及保肾康对系膜增殖型肾炎有治疗作用。． |
| 关 键 词： | 活血化瘀药物 抗Thy-1抗体肾炎 实验研究 补肾活血汤 保肾康 增殖细胞核抗原 |
The experiment study of removing blood stasis Chinese herbs on glomerulonephritis due to anti - Thy - 1 antibody |
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| DA Zhanyun,CUI Shiwei,QIAN Tongsun,et al Division of Nephrology,Affiliated hospital of Nantong Medical College,Jiangsu,Nantong. The experiment study of removing blood stasis Chinese herbs on glomerulonephritis due to anti - Thy - 1 antibody[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2000, 1(1): 14-17 | |
| Authors: | DA Zhanyun CUI Shiwei QIAN Tongsun et al Division of Nephrology Affiliated hospital of Nantong Medical College Jiangsu Nantong |
| Abstract: | Objective To explore the therapeutic effects and mechanism of removing blood stasis Chinese herbs on glomerulonephritis due to anti - Thy - 1 antibody. Methods Glomerulonephritis due to anti -Thy - 1 antibody was utilized in rats . As compared with prednisone, the interfering effect of Bushen Decoction and Baoshenkang Tablets on this model was investigated. Paraffin - embedded renal tissue sections of all Wistar rats were examined by using immunohistochemical staining (SP method) with anti - proliferating cell nuclear antigen (PCNA) monoclonal antibody (clone PC10). Results Proteinuria and hematuria of treatment groups were alleriated. The pathological damage and PCNA cell in tubules and interstitial of treatment groups were less severe in comparison with the control group. ' Conclusion Bushen Decoction and Baoshenkang Tablets have therapeutic effects on the experiment mesangial proliferative glomerulonephritis. |
| Keywords: | Glomerulonephritis due to anti-Thy-1 antibody Bushen Decoction Baoshenkang Tablets Proliferating cell nuclear antigen |
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