阿立哌唑替换利培酮治疗对精神分裂症患者血清催乳素水平的影响

目的:研究阿立哌唑替换利培酮治疗对精神分裂症患者血清催乳素水平的影响。方法:伴有高催乳素血症的精神分裂症患者128例,随机分为利培酮组(维持利培酮治疗)和阿立哌唑(阿立哌唑替代利培酮治疗)组,治疗8周。于第0、1、2、4、6及8周测血清催乳素水平及身体质量指数(BMI);在入组时和治疗8周时采用阳性与阴性症状量表(PANSS)和临床总体印象量表(CGIS)测定疗效。结果:可用于评估的数据101例,利培酮组53例,阿立哌唑组48例。阿立哌唑组替换治疗后第1周血清催乳素水平即明显下降,第8周时,显著低于利培酮组(P<0.001);2组BMI、PANSS及CGIS评分及变化差异无统计学意义。结论:阿立哌唑替换利培酮可降低伴有高催乳素血症的精神分裂症患者的血清催乳素水平。

Comparison of Efficacy and Prolactin Concentrations between Aripiprazole and Risperidone Treatments in Patients with Schizophrenia

Objective: To compare the prolactin concentrations between aripiprazole and risperidone treatment in patients with schizophrenia.Methods: One hundred and twenty-eight schizophrenic patients with hyperprolactinemia were randomly divided into risperidone group and aripiprazole group.Patients in the risperidone group were treated with risperidone and in the aripiprazole group were treated with aripiprazol instead of risperidone for 8 weeks.The prolactin concentrations were assessed and compared between two groups at weeks 0,1,2,4,6,and 8.The clinical status was assessed by using the positive and negative syndrome scale(PANSS) and the clinical global impressions scale(CGIS) at weeks 0 and 8.Results: Fifty-three in the risperidone group and 48 in the aripiprazole group were available for analyzing.Shift risperidone to aripiprazole was effective in reducing serum prolactin levels.The serum prolactin levels in the risperidone group was significantly lower than that in the aripiprazole group at week 8(P<0.001).No significant changes was found in the PANSS and CGI-S scores between the two groups.Conclusion: Shift risperidone to aripiprazole was effective in reducing serum prolactin levels of schizophrenia patients with hyperprolactinemia.