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| 藏药大花龙胆正丁醇部位的化学成分研究 | |
| 引用本文： | 付林,古锐,张彩虹,李甫,钟世红,马逾英,邓薇. 藏药大花龙胆正丁醇部位的化学成分研究[J]. 中草药, 2018, 49(5): 1002-1006 |
| 作者姓名： | 付林 古锐 张彩虹 李甫 钟世红 马逾英 邓薇 |
| 作者单位： | 成都中医药大学药学院, 四川 成都 611137,成都中医药大学民族医药学院, 四川 成都 611137,成都中医药大学药学院, 四川 成都 611137,中国科学院成都生物研究所, 四川 成都 610041,成都医学院药学院, 四川 成都 610083,成都中医药大学药学院, 四川 成都 611137,成都中医药大学民族医药学院, 四川 成都 611137 |
| 基金项目： | 国家自然科学基金青年项目：不同化学表型藏药白花龙胆"异质同效"的药效物质基础及功能基因差异研究（81603395）;成都中医药大学科学发展基金成果转化项目：藏药龙胆花健康产品转化（CGPY1604） |
| 摘 要： | 目的研究藏药大花龙胆Gentiana szechenyii花枝乙醇提取物的正丁醇部位的化学成分。方法通过制备高效液相色谱法分离纯化,利用各种谱学技术鉴定化合物的结构。结果从大花龙胆花枝乙醇提取物的正丁醇部位分离得到6个化合物,分别鉴定为大花龙胆酯苷A(1)、大花龙胆苷A(2)、异金雀花素-2″-O-吡喃葡萄糖苷(3)、异金雀花素(4)、乌奴龙胆苷D(5)和平龙胆酯苷(6)。结论化合物1为1个新的环烯醚萜苷类化合物,命名为大花龙胆酯苷A。 |
| 关 键 词： | 大花龙胆 环烯醚萜苷 大花龙胆酯苷A 大花龙胆苷A 异金雀花素 乌奴龙胆苷D 平龙胆酯苷 |
| 收稿时间： | 2017-10-19 |
Chemical constituents of n-butanol fraction from Tibetan medicine Gentianae Szechenyii Spray |
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| FU Lin,GU Rui,ZHANG Cai-hong,LI Fu,ZHONG Shi-hong,MA Yu-ying and DENG Wei. Chemical constituents of n-butanol fraction from Tibetan medicine Gentianae Szechenyii Spray[J]. Chinese Traditional and Herbal Drugs, 2018, 49(5): 1002-1006 | |
| Authors: | FU Lin GU Rui ZHANG Cai-hong LI Fu ZHONG Shi-hong MA Yu-ying DENG Wei |
| Affiliation: | College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China,College of Pharmacy, Chengdu Medical College, Chengdu 610083, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China and College of Ethnomedicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
| Abstract: | Objective To investigate the chemical constituents of n-butanol fraction of the ethanol extracts from spray of Gentianae szechenyii. Methods The chemical constituents were isolated and purified by repeated preparative high-performance liquid chromatography. The structures of the isolated compounds were identified on the basis of extensive spectroscopic techniques. Results Six compounds were obtained in n-butanol fraction of the ethanol extracts from G. szechenyii and identified as gentizechenlioside A (1), szechenyin A (2), isoscoparin-2"-O-glucopyranoside (3), isoscoparin (4), gentiournosides D (5), and depressine (6). Conclusion Compound 1 is a new iridoid glycoside which named as gentizechenlioside A. |
| Keywords: | Gentiana szechenyii Kanitz iridoid glycoside gentizechenlioside A szechenyin A isoscoparin gentiournosides D depressine |
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