| 补肾活血方的急性肝损伤保护作用 |
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| 引用本文： | 朱萱萱,吴旭同,倪文彭,丁扬.补肾活血方的急性肝损伤保护作用[J].中国医药导刊,2008,10(7):1071-1072. |
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| 作者姓名： | 朱萱萱 吴旭同 倪文彭 丁扬 |
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| 作者单位： | 南京中医药大学附属医院药理室,南京,210029 |
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| 摘 要： | 目的：研究补肾活血方对氢化可的松致肾阴虚小鼠急性肝损伤的保护作用。方法：采用四氯化碳和扑热息痛制作急性肝损伤模型，观察补肾活血方对肝系数、GOT和GPT以及肝损伤的病理组织学检查。结果：补肾活血方可使四氯化碳和扑热息痛致急性肝损伤肾阴虚小鼠血清GPT、GOT降低，病理组织学结果表明补肾活血方各剂量组可明显减轻扑热息痛造成小鼠肝脏坏死及肝细胞变性，甚至病变消退，肝细胞水肿范围明显缩小。结论：补肾活血方对四氯化碳和扑热息痛致急性肝损伤肾阴虚小鼠具有保护作用。
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| 关 键 词： | 补肾活血方 急性肝损伤 GOT和GPT 病理组织学 |
Bushenhuoxuefang in Protection of Acute Hepatic injury |
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| Zhu Xuan-xuan,Wu Xutong,Li Wen-peng,et al..Bushenhuoxuefang in Protection of Acute Hepatic injury[J].Chinese Journal of Medicinal Guide,2008,10(7):1071-1072. |
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| Authors: | Zhu Xuan-xuan Wu Xutong Li Wen-peng |
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| Institution: | Zhu Xuan-xuan,Wu Xutong,Li Wen-peng,et al. (Nanjing university of Chinese medical affaliated hospital Phormaco-room Nanjing 210029) |
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| Abstract: | Objective:Researched Bushenhuoxuefang in protection of Hydrocortisone caused acute hepatic injury.Method:Used CCL4 and Paracetamol to make acute hepatic injury model,observed Bu shen huo xue fang in liver-quotiety,GOT,GPT and histopathologic examination of hepatic injury.Results:Bushenhuoxuefang made GOT,GPT of CCL4 and Paracetamol caused acute hepatic injury deficiency of kidney-YIN mouse serum cut down.Histopathologic result indicated every dose group of Bu shen huo xue fang could ease Paracetamol to resu... |
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| Keywords: | Bushenhuoxuefang Acute hepatic injury GOT and GPT Histopathology |
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