儿童甲型H1N1流感12例分析

目的 了解儿童甲型H1N1流感的特点.方法 回顾分析2009年5月1日至2009年7月15日复旦大学附属儿科医院发热门诊及病房诊治的12例甲型H1N1流感的流行特征及临床特点;采取患儿鼻咽拭子标本,冰壶保存立即送上海市疾病预防控制中心,采用实时逆转录核酸扩增聚合酶链反应(RT-PCR)进行甲型H1N1流感病毒核酸检测.结果 12例儿童甲型H1N1流感均为输入性病例,5例患儿有明确的甲型H1N1流感患者密切接触史.12例有发热症状,有咳嗽、流涕、食欲不佳症状的各为7例,1例有喘息症状,所有病例均无呕吐和腹泻.11例能准确表述自身感受的患儿中,均无肌肉酸痛,6例有咽痛,3例有腹痛.2例患儿并发肺炎,其中1例患儿病情危重.1例患儿居家隔离对症治疗,11例患儿住院治疗,均参照中国国家卫生部颁布的<甲型HINI流感诊疗方案(2009年试行版第一版)>进行治疗,其中10例息儿接受奥斯他韦抗病毒治疗,未见明显不良反应,所有患儿均痊愈.结论 儿童甲型H1N1流感的症状主要表现为典型的流感症状,大部分患儿临床过程轻微,及时隔离和治疗预后良好,奥斯他韦抗病毒治疗无明显副作用.儿童甲型H1N1流感的流行特征及临床特点尚需要多地区大样本的研究资料.

Analysis of l2 children with novel influenza A (H1N1) virus infection

Objective Since late March 2009,a novel influenza H1N1 strain emerged in humans in Mexico and the United States.It has rapidly spread to many countries on different continents,prompting unprecedented activation of pandemic preparedness plans.The present study aimed to investigate the characteristics of children with the novel influenza A(H1N1)virus infection.Method Twelve csges with influenza A(H1N1)infection were diagnosed according to the criteria of the Center for Disease Control and Prevention(CDC)of China during 1 May to 15 July 2009 in the Pediatric Hospital of Fudan University were analyzed.Influenza A(HINI)RNA was detected by RT-PCR in CDC Shanghai China.Result All the 12 children with the novel influenza A(H1N1)virus infection were imported cases,aged from 11 months to 14 years 7 months,7 of whom were boys,5 were girls.Five cases contacted closely with influenza A (H1N1)patients;12 cases had fever and no vomiting or diarrhea;7 had cough or runny noge or anorexia.One had shortness of breath the Of the 11 cases who could tell about symptoms correctly,6 had sore throat,3 had stomachache,and none had muscle pain. Two of the 12 cases had pneumonia,and the disease in 1 of them was fatal and needed intensive care. One case was isolated and treated at home.The 11 cases hospitalized were treated according to the guidance of influenza A(H1N1)diagnosis and treatment issued by the Ministry of Health of China.Ten hospitalized cases were treated with osehamivir.All the cases recovered completely.The median length of hospital stay was 8.1 days(range,6 to 16),and the time of negative test results of influenza A(H1N1)RNA from illness onset to collection of samples for viral testing was from 5 to 15 days.Conclusion Symptoms among children with the novel influenza A(H1N1)virus infection were classic and the majority of the cases we treated had a mild clinical course if they were isolated and treated promptly.Antivirals appears to have not had any major adverse effects.More data from different regions and large samples are needed to illuminate the characteristics of children with novel influenza A(H1N1)virus infection.