双黄连粉针与常见注射剂配伍稳定性考察

目的:考察双黄连粉针和9种注射剂配伍的稳定性。方法:采用0.9%氯化钠溶液作为溶媒,考察双黄连粉针与9种注射剂在室温下配伍后外观、pH和微粒变化,并采用HPLC法考察配伍液中黄芩苷含量的变化。结果:双黄连粉针与头孢呋辛钠粉针配伍产生白色沉淀,含量下降;与碳酸氢钠注射液配伍颜色加深,pH略微升高,含量下降;与盐酸肾上腺素注射液含量下降。结论:双黄连粉针不宜与头孢呋辛钠粉针、碳酸氢钠注射液、盐酸肾上腺素注射液配伍,可与其他药物配伍应用。

Study on Compatible Stability of Shuanghuanglian Powder Injection and Common Injection

Objective: To study the compatible stability of Shuanghuanglian powder injection and 9 common injection. Method : The samples of complexes with the sodium chloride solution as a solvent were collected at room temperature to study the changes of appearanc, pH and to determine content by using HPLC method. Result : White precipitate produced and then content decreased after mixing Shuanghuanglian powder injection with cefuroxime sodium injection. deepened color, pH slightly increased and content decreased after mixing Shuanghuanglian powder with sodium bicarbonate injection and hydrochloric acid injection. Conclusion: Shuanghuanglian powder could not combine with cefuroxime sodium powder for injection or sodium bicarbonate injection, but can combine with other drugs.