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| PEDF在糖尿病微血管病变中的抗氧化作用 | |
| 引用本文： | 胡莹洁. PEDF在糖尿病微血管病变中的抗氧化作用[J]. 医学综述, 2011, 17(13): 2004-2006 |
| 作者姓名： | 胡莹洁 |
| 作者单位： | 武汉大学人民医院内分泌科,武汉,430060 |
| 摘 要： | 色素上皮衍生因子(PEDF)是一种多功能蛋白,具有神经营养、抗肿瘤、抗氧化、抗新生血管等多种功能。近年来有研究表明,PEDF在糖尿病微血管病变中发挥重要作用,它通过抗氧化效应抑制活性氧簇的表达延缓了糖尿病微血管病的发生发展。因此,对PEDF抗氧化效应的深入研究有利于了解PEDF与糖尿病微血管病的关系,PEDF可能成为临床治疗的一种新方向。 |
| 关 键 词： | 色素上皮衍生因子 氧化应激 抗氧化 糖尿病微血管病变 |
The Antioxidant Effect of PEDF in Diabetic Microangiopathy |
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| HU Ying-jie. The Antioxidant Effect of PEDF in Diabetic Microangiopathy[J]. Medical Recapitulate, 2011, 17(13): 2004-2006 | |
| Authors: | HU Ying-jie |
| Affiliation: | HU Ying-jie,LI Jing.(Department of Endocrinology,Renmin Hospital,Wuhan University,Wuhan 430060,China) |
| Abstract: | Pigment epithelium-derived factor(PEDF)is a glycoprotein famous for its complex neurotrophic,antineoplastic,anti-oxidative and anti-angiogenic properties.Recent studies show that PEDF play an important role in diabetic microangiopathy,which inhibits the expression of reactive oxygen species by its antioxidant effect,thereby delays the development of diabetic microangiopathy.Therefore,intensive study of PEDF′s antioxidant effects is conducive to the understanding of the relationship between PEDF and diabetic microangiopathy;PEDF may become a new target for clinical treatment. |
| Keywords: | Pigment epithelium-derived factor Oxidative stress Anti-oxidative Diabetic microangiopathy |
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