| 肿瘤治疗靶点survivin及其分子拮抗剂的研究进展 |
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| 引用本文： | 黄玮琳,周向军,王永祥. 肿瘤治疗靶点survivin及其分子拮抗剂的研究进展[J]. 中国药理学通报, 2005, 21(4): 389-392 |
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| 作者姓名： | 黄玮琳 周向军 王永祥 |
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| 作者单位： | 上海交通大学药学院,上海,200030 |
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| 摘 要： | survivin是IAP家族成员之一,分布于有丝分裂元件,具有调控细胞有丝分裂和抑制细胞凋亡的功能。survivin在大多数正常组织中未被检测,但在肿瘤组织中过量表达。survivin作为癌症治疗的一个重要靶点,针对survivin的多种分子拮抗剂的研究已经取得了一定成果。
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| 关 键 词： | survivin 肿瘤 靶点 分子拮抗剂 |
| 文章编号： | 1001-1978(2005)04-0389-04 |
| 修稿时间： | 2004-09-20 |
Recent advances in research on survivin and its moecular antagonists |
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| HUANG Wei-lin,ZHOU Xiang-jun,WANG Yong-xiang. Recent advances in research on survivin and its moecular antagonists[J]. Chinese Pharmacological Bulletin, 2005, 21(4): 389-392 |
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| Authors: | HUANG Wei-lin ZHOU Xiang-jun WANG Yong-xiang |
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| Abstract: | Survivin is a member of the IAP family, which has been shown to localize to various components of the mitotic apparatus. Survivin is not only an apoptosis inhibitor, but a mitotic regulator as well. Survivin is Absolutely undetectable in normal tissues, but over-expressed in all the most common human cancers. Survivin is considered as an important target in cancer treatment, and the research on its molecular antagonists has gained encouraging achievements. |
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| Keywords: | survivin |
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