益心酮片对大鼠心肌缺血的保护作用

目的 :造成不同实验性心肌缺血模型 ,观察益心酮抗心肌缺血的作用。方法 :采用结扎法和药物法(垂体后叶素、异丙肾上腺素 )造成实验性急性心肌缺血模型 ,观测心电图、血流动力学和形态学指标。结果 :本药以 100 ,200mg·kg^-1的剂量给大鼠灌服 ,对结轧冠脉左前降支 30min所致缺血再灌注模型 ,有恢复心率、血压、左室舒张末期压、左室内压及其最大上升、下降速率 (±dp/dt_max)和心电图ST段的作用 ;亦能显著缩小冠脉结扎大鼠的心肌梗死面积 ;对注射垂体后叶素 (iv)和异丙肾上腺素 (ip)所致急性心肌缺血模型 ,有逆转ST段偏移与T波降低的保护作用。结论 :益心酮对实验性心肌缺血具有保护作用和治疗作用。

Yixintong Tablet''s Protection Against Experimental Myocardial Ischemia

Objective: Various models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia. Method: models of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline ) to check the indices of ECG, hemodynamics, and morphology. Result: A dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Yixintong tablets exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (±dp/dt_max ), and ST segment (electrocardiogram). The tablet markedly reduced the myocardial infarct size of the coronary ligatured rats. The tablet benefited the rats with pituitrin(iv) or isoprenaline(ip) induced acute myocardial ischemia to reverse any ST deviation and T wave fall. Conclusion: Yixintong has a protective and therapeutic action to the experimental myocardial ischemia.