探讨T1和T2期直肠癌淋巴结转移特点及预后

目的:探讨T1和T2期直肠癌淋巴结的转移特点及预后.方法:回顾性分析120例T1和T2期直肠癌淋巴结的转移特点,用x2检验分析其相关因素,并对预后进行单因素分析.结果:T1和T2期直肠癌行Mile's术66例,行Dixon术54例,淋巴结转移率为20.0％(24/120),经分析,肿瘤的分化程度与淋巴结转移有关,5年生存率91.60％,肿瘤组织学类型,浸润程度,分化程度与淋巴结转移有关RR=0.2250,RR=0.3088.结论:T1和T2期直肠癌均可发生淋巴结转移,肿瘤分化程度与淋巴结转移有关(r=0.235),根治性切除效果较好,可以作为首选的治疗方法.

Lymph Node Metastasia and Prognosis in T1 and T2 Rectal Carcinoma

Objective:To investigate the characteristics of lymph node metastasis and prognosis of T1/T2 rectal carcinoma.Methods: The clinical data of 120 patients with T1 orT2 rectal carcinoma were retrospectively analyzed.The factors relative to lymph node metastasis were analyzed using Chi-square test.The survival data were analyzed using Kaplan-Meiermethod.The factors influencing survival were analyzed using univariate(Long-rank) methods.Results:The 120 patients,66 received Mile’s operation and 54 underwent Dixon operation,The overall lymph node metastasis rate was 20%(24/120).The lymph node metastasis was significantly correlated with histological differentiation as revealed by Chi-square test.The overall 5-year survival rate for the whole series group was 91.6%.Univariate analysis revealed that tumor histological type,intramural infiltration,differentiation is related to lymph node metastasis(RR=0.2250,RR=0.3088).Conclusion: Even though lymph node metastasis can be observed either in T1 or T2 rectal carcinoma,histological differentiation is significantly related to the lymph node metastasis(r=0.235).As radical resection achieve better survival than local resection,it should be suggested as the chief treatment forT1/T2 rectal carcinoma.