| 急性缺氧大鼠的心输出量和局部血流量 |
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| 引用本文： | 罗德成,高京生,刘士群,王强,田景亮,王仕军. 急性缺氧大鼠的心输出量和局部血流量[J]. 中国病理生理杂志, 1988, 0(1) |
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| 作者姓名： | 罗德成 高京生 刘士群 王强 田景亮 王仕军 |
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| 作者单位： | 第三军医大学病理生理学教研室(罗德成，高京生，刘士群，王强，田景亮)，第三军医大学病理生理学教研室(王仕军) |
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| 摘 要： | 以~(99m)Tc标记蟾蜍红细胞(~(99m)Tc-RBC)作为生物微球,用参考血样本方法(RSM)测定急性缺氧大鼠的心输出量(CO)和局部血流量(LBF)。大鼠在麻醉条件下进行人工通气,用10%O~2—90%N_2混合气体通气20分钟造成急性缺氧,左心室内注入~(99m)Tc-RBC 4～6万,从股动脉收集参考血样本(RS)测定CO和LBF,实验结果表明,在人工通气条件下,急性缺氧使大鼠的心率(HR)减慢、CO降低,和以冠状血流和脑血流增加及内脏血流减少为主的血流重新分配。
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| 关 键 词： | 缺氧症 心排出量 局部血流 |
Cardiac output and local blood flow in acute hypoxic rat |
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| Luo De-Cheng,et al. Cardiac output and local blood flow in acute hypoxic rat[J]. Chinese Journal of Pathophysiology, 1988, 0(1) |
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| Authors: | Luo De-Cheng et al |
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| Affiliation: | Luo De-Cheng,et al Department of Pathophysiology,The Third Military Medical College,Chongqing |
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| Abstract: | Measurement of the cardiac output and local blood flow was accomplished in acute hypoxic rat with ~(99m)Tc-labeled toad red blood cells (~(99m)Tc-RBC) as biologic microspheres and the reference sample method (RSM). Hypoxia was produced by switching from room air to an 10% O_2-90%N_2 gas mixture. 40000-60000 of ~(99m)Tc-RBC were injected into the left ventricle of anaesthetized, artificially aerated rat and the reference sample was withdrawn from femoral arterial cannula in order to measure the cardiac output and local blood flow after 20 minutes inhaling hypoxic gas mixture. Results indicate that under a condition of artificial ventilation, acute hypoxia results in decrease of cardiac output and heart rate, and redistribute blood flow away from splanchmic organs to the heart and brain. |
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| Keywords: | Anoxia Cardiac output Regional blood flow |
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