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| 抗人类免疫缺陷病毒新药：D-D4FC | |
| 引用本文： | 蒋波,戚娜,朱利民. 抗人类免疫缺陷病毒新药：D-D4FC[J]. 中国新药与临床杂志, 2008, 27(5) |
| 作者姓名： | 蒋波 戚娜 朱利民 |
| 基金项目： | 上海市科委浦江人才计划 |
| 摘 要： | β-D-2′,3′-双脱氢双脱氧-5-氟胞苷(D-D4FC)是一种新型抗人类免疫缺陷病毒(HIV)的核苷类药物,可有效抑制HIV病毒株及其变异株。D-D4FC与大多数抗病毒抑制药联合用药无相互抑制作用,几乎无细胞毒性,是一种极具潜力的抗HIV药物。目前,D-D4FC正在美国,法国和德国进行Ⅱ期临床试验,其Ⅲ期临床试验也正计划启动。 |
| 关 键 词： | 获得性免疫缺陷综合征 HIV 抗HIV药 药物疗法 D-D4FC |
Anti-HIV new drug:D-D4FC |
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| JIANG Bo,QI Na,ZHU Li-min. Anti-HIV new drug:D-D4FC[J]. Chinese Journal of New Drugs and Clinical Remedies, 2008, 27(5) | |
| Authors: | JIANG Bo QI Na ZHU Li-min |
| Abstract: | β-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine (D-D4FC) is a new nucleoside analogue with combination potency of inhibition against wild-type HIV and its variants.D-D4FC possesses no correlative resistance with almost no toxicity on mitochondrion in combination application with the most other antiviral inhibitors.Meanwhile,D-D4FC is carrying on its phaseⅡclinical trial in America,France and Germany and the phaseⅢis now planning in progress. |
| Keywords: | acquired immunodeficiency syndrome HIV anti-HIV agents drug theray D-D4FC |
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