心包腔化疗联合体外高频热疗治疗肺癌伴心包积液

目的探讨心包腔灌注顺铂化疗联合体外高频热疗治疗肺癌伴恶性心包积液的疗效。方法63例患者分成甲组30例、乙组33例，甲组先行心包腔穿刺引流，再向心包腔内灌注顺铂60mg＋地塞米松10mg，第1、8天。第8天灌注药物后即拔除引流管，然后行心包区域体外深部热疗，隔3天1次，共热疗2次。乙组除不进行热疗外，其余治疗均与甲组相同。结果甲组CR21例、PR6例、NC3例，总有效率90．0％；乙组CR17例、PR8例、NC8例，总有效率75．8％，P〈0．05。结论心包腔灌注顺铂治疗肺癌伴恶性心包积液有效，在此基础上联合体外高频热疗可以提高疗效。

Pericardial cavity chemotherapy combined with external high frequency thermotherapy in the treatment of malignant pericardial effusion caused by lung cancer

Objective To evaluate the efficacy of cisplatin chemotherapy combined with external high frequency thermotherapy in the treatment of patients with malignant pericardial effusion caused by lung cancer. Methods All of the patients were treated with intra- cavitary paracentesis and drainage at first, and then they were injected with 60 mg of elsplatln and l0 mg of dexamethasone on the first and eighth days. Then they were divided into the group A （ n = 30） and the group B （ n = 33 ）. After the eighth clays, the group A were given external high frequency thermotherapy additionally every 3 days. Results The clinical objective response was 90% （70% CR and 20% PR） in the group A, and the clinical objective response was 75.8% （51.5% CR and 24. 2% PR） in the group B. The difference of the total effective rate between the two groups was significant （ P 〈 0.05 ）. Conclusion On the basis of intraeavitary injection of eisplatin chemotherapy, the external high frequency thermotherapy can significantly improve the curative effect in treatment of malignant perleardial effusion caused by lung cancer.