| 前蛋白转化酶枯草溶菌素9与心肌梗死之间关系的研究进展 |
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| 引用本文： | 徐金,彭瑜,张钲.前蛋白转化酶枯草溶菌素9与心肌梗死之间关系的研究进展[J].中国动脉硬化杂志,2021,29(11):1000-1006. |
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| 作者姓名： | 徐金 彭瑜 张钲 |
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| 作者单位： | 兰州大学第一临床医学院,甘肃省兰州市730000;甘肃省心血管疾病重点实验室,甘肃省兰州市730000;兰州大学第一医院心脏中心,甘肃省兰州市730000;甘肃省心血管疾病重点实验室,甘肃省兰州市730000 |
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| 基金项目： | 甘肃省心血管疾病重点实验室建设项目(1206RTSA025),甘肃省心血管病临床医学研究中心(甘科技[2018]20号) |
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| 摘 要： | 前蛋白转化酶枯草溶菌素9(PCSK9)是一类前蛋白转化酶家族蛋白酶K亚家族成员,可以和低密度脂蛋白受体(LDLR)结合,阻抑了LDLR的重复利用,导致肝细胞表面LDLR减少,使外周血中低密度脂蛋白胆固醇(LDLC)水平增加,从而导致血脂代谢异常等一系列病理生理过程。目前研究表明PCSK9与心肌梗死存在一定的相关性,并可能通过独立于LDLC之外的途径调控心肌梗死的发生发展。本文就PCSK9与心肌梗死的相关研究进展进行综述。
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| 关 键 词： | 前蛋白转化酶枯草溶菌素9 心肌梗死 基因多态性 血小板活化 |
| 收稿时间： | 2021/1/9 0:00:00 |
| 修稿时间： | 2021/7/6 0:00:00 |
Research progress on the relationship between proprotein convertase subtilisin/kexin type 9 and myocardial infarction |
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| XU Jin,PENG Yu,ZHANG Zheng.Research progress on the relationship between proprotein convertase subtilisin/kexin type 9 and myocardial infarction[J].Chinese Journal of Arteriosclerosis,2021,29(11):1000-1006. |
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| Authors: | XU Jin PENG Yu ZHANG Zheng |
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| Institution: | The First Clinical Medicine School of Lanzhou University, Lanzhou, Gansu 730000;The Key Laboratory of Cardiovascular Diseases of Gansu Province, Lanzhou, Gansu 730000;The Heart Center of the First Hospital of Lanzhou University, Lanzhou, Gansu 730000;The Key Laboratory of Cardiovascular Diseases of Gansu Province, Lanzhou, Gansu 730000 |
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| Abstract: | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of the proprotein convertase family, which can combine with low-density lipoprotein receptor (LDLR), and inhibit the repeated use of LDLR, resulting in a decrease in LDLR on the surface of liver cells, an increase in LDL levels in peripheral blood and a series of pathophysiological processes such as abnormal blood lipid metabolism. Current studies have shown that PCSK9 has a certain correlation with myocardial infarction, and may regulate the occurrence and development of myocardial infarction through a way independent of low-density lipoprotein cholesterol (LDLC). This article will review the research progress of PCSK9 and myocardial infarction. |
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| Keywords: | proprotein convertase subtilisin/kexin type 9 myocardial infarction gene polymorphism platelet activation |
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