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| microRNA对基质金属蛋白酶2和基质金属蛋白酶9的调控及其在主动脉瘤发生发展中的作用 | |
| 引用本文： | 徐海强,宗圆,万恒佺,赵思敏,王佐,王贵学,屈顺林,李国华. microRNA对基质金属蛋白酶2和基质金属蛋白酶9的调控及其在主动脉瘤发生发展中的作用[J]. 中国动脉硬化杂志, 2022, 30(6): 529-534 |
| 作者姓名： | 徐海强 宗圆 万恒佺 赵思敏 王佐 王贵学 屈顺林 李国华 |
| 作者单位： | 南华大学衡阳医学院基础医学院病理生理学教研室,湖南省衡阳市421001;重庆大学生物工程学院生物流变科学与技术教育部重点实验室,重庆市400030 |
| 基金项目： | 国家自然科学基金青年项目(81900424)；湖南省教育厅科研项目(20B493)；衡阳市科技计划项目(2019yj010683)；生物流变科学与技术教育部重点实验室(重庆大学)(CQKLBST-2018-010) |
| 摘 要： | 主动脉瘤(AA)是一种发病率和死亡率都很高的心血管疾病，且发病机制极其复杂。研究证实microRNA(miRNA)可以调节AA的多种病理生理过程，包括炎症、细胞外基质(ECM)重构、血管平滑肌细胞增殖和死亡等。基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)是MMP蛋白酶家族中的重要成员，同样在AA的上述病理生理过程中起着重要作用。近年来发现多种miRNA可通过直接或间接的方式调节AA中MMP-2和MMP-9的表达和活性，从而影响AA的发生发展。文章主要总结了miRNA对MMP-2、MMP-9的调控机制及其在AA病变中的作用，旨在为AA的诊断和治疗提供新思路。 |
| 关 键 词： | 主动脉瘤 microRNA 基质金属蛋白酶2 基质金属蛋白酶9 |
| 收稿时间： | 2022-01-17 |
| 修稿时间： | 2022-03-25 |
Role of microRNA in regulating matrix metalloproteinase-2 and matrix metalloproteinase-9 in aortic aneurysm |
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| XU Haiqiang,ZONG Yuan,WAN Hengquan,ZHAO Simin,WANG Zuo,WANG Guixue,QU Shunlin,LI Guohua. Role of microRNA in regulating matrix metalloproteinase-2 and matrix metalloproteinase-9 in aortic aneurysm[J]. Chinese Journal of Arteriosclerosis, 2022, 30(6): 529-534 | |
| Authors: | XU Haiqiang ZONG Yuan WAN Hengquan ZHAO Simin WANG Zuo WANG Guixue QU Shunlin LI Guohua |
| Affiliation: | Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China;Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400030, China |
| Abstract: | Aortic aneurysm (AA) is a cardiovascular disease with high morbidity and mortality. Its pathogenesis is extremely complex. Studies have confirmed that microRNA (miRNA) can regulate numerous pathophysiological processes, including inflammation, extracellular matrix (ECM) remodeling, and vascular smooth muscle cell (VSMC) proliferation and death, in AA. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are important members of the MMP family, which also play an important role in the pathological process of AA. In recent years, it has been found that a variety of miRNA can directly or indirectly regulate the expression and activity of MMP-2 and MMP-9 in AA, thus affecting the occurrence and development of AA. This paper mainly summarizes the regulatory mechanisms of miRNA on MMP-2, MMP-9 and their roles in the occurrence and development of AA, so as to provide new ideas for the diagnosis and treatment of AA. |
| Keywords: | aortic aneurysm microRNA matrix metalloproteinase-2 matrix metalloproteinase-9 |
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