| CYP2C19基因多态性对药物代谢的影响及其个体化用药 |
| |
| 引用本文： | 严非,夏春华,熊玉卿. CYP2C19基因多态性对药物代谢的影响及其个体化用药[J]. 中国临床药理学与治疗学, 2010, 15(8): 949-953 |
| |
| 作者姓名： | 严非 夏春华 熊玉卿 |
| |
| 作者单位： | 南昌大学医学院临床药理研究所,江西南昌330006 |
| |
| 摘 要： | CYP2C19是一种重要的药物代谢酶,参与多种药物的体内代谢。该酶的活性在不同个体和种族之间存在着显著的差异。本文综述了CYP2C19酶的基因多态性对药物代谢的影响,以期为指导临床合理用药打下坚实的理论基础,确保临床用药的安全性和有效性,真正的实现个体化用药。
|
| 关 键 词： | CYP2C19 基因多态性 药物代谢 个体化用药 |
Effect of CYP2C19 genetic polymorphism on drug metabolism and individualized therapy |
| |
| YAN Fei,XIA Chun-hua,XIONG Yu-qing. Effect of CYP2C19 genetic polymorphism on drug metabolism and individualized therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(8): 949-953 |
| |
| Authors: | YAN Fei XIA Chun-hua XIONG Yu-qing |
| |
| Affiliation: | Institute of Clinical Pharmacology,Medical College of Nanchang University,Nanchang 330006,Jiangxi,China |
| |
| Abstract: | CYP2C19 is an important durg-metabolizing enzyme involved in the metabolism of a variety of drugs in vivo.The enzymatic activity is significantly different in different individuals and races.This paper is about the effect of CYP2C19 genetic polymorphism on drug metabolism,in order to lay down a solid theory foundation for the guidance in clinical rational administration,ensure the safety and effectiveness of clinical usage,achieving individualized therapy in its true sense. |
| |
| Keywords: | CYP2C19 Genetic polymorphism Drug metabolism Individualized therapy |
| 本文献已被 维普 万方数据 等数据库收录！ |
