AECOPD患者院内继发肺部真菌感染的临床分析

目的探讨慢性阻塞性肺疾病急性加重期（acute exacerbation chronic obstructive pulmonary disease。AECOPD）肺部真菌感染的临床特点、相关因素及疗效。方法回顾性分析了2008年1月至2009年12月间AECOPD院内继发肺部真菌感染患者46例．并随机抽取相同时期无真菌感染的AECOPD患者46例作对比分析。结果AECOPD院内继发肺部真菌感染患者临床表现无特异性，病原菌以白色念珠菌为主。长期使用广谱高效抗生素和糖皮质激素、低蛋白血症、合并糖尿病以及机械通气是AECOPD院内继发真菌感染的主要危险因素。结论合理正确使用抗生素及糖皮质激素，预防医源性感染，加强营养，尽量缩短住院天数是降低AECOPD院内继发真菌感染发生率的关键因素。

Clinical Analysis of Aecopd Patients with Secondary Pulmonary Fungal Infection in the Hospital

Objective To investigate the clinical characteristics and the values of the relevant factors in patients with chronic obstructive pulmonary disease and acute exacerbation （AECOPD） pulmonary fungal infection. Methods Data from 46 AECOPD patients, between January 2008 to December 2009, with secondary pulmonary fungal infection were collected and retrospectively analyzed.Data from another 46 AECOPD patients without fungal infection were used for comparison. Results AECOPD nosocomial fungal infections in patients with secondary pulmonary performance of non-specific clinical surgery.The causative agent was mainly Candida albicans.Using the broad-spectrum antibiotics,long-term use of glucocorticoids, hypoproteinemia, diabetes mellitus as well as mechanical ventilation are the risk factors associated with the fungal infection in the hospital. Conclusion Rational use of antibiotics and cortieosteroids, better nutrition and shortening the period of hospitalization are the key to reduce the incidence of secondary fungal infection in these patients.