磷酸萘酚喹伍用青蒿素对猴疟原虫的药效学研究

目的 研究磷酸萘酚喹与青蒿素伍用对猴疟的治疗作用。 方法 感染诺氏疟原虫恒河猴模型随机均分为9组（3只/组）,A组和B组分别灌服6和10 mg/kg磷酸萘酚喹3 d,1次/d;C组和D组分别灌服31.6和100 mg/kg青蒿素,第1天2次,第2～3天各1次;E组、F组和G组用10 mg/kg磷酸萘酚喹分别与10、20和25 mg/kg青蒿素配伍（即以1?誜1、1?誜2和1?誜2.5配伍）灌服;H组和I组分别灌服单药磷酸萘酚喹10 mg/kg和青蒿素30 mg/kg。于给药后24 h观察原虫感染率,以给药后105 d查不见原虫为治愈标准。 结果 给药后24 h,A、B、C、D组原虫下降率均超过90%。E、F和G组平均原虫转阴时间依次为（56.0±16.0）、（53.3±4.6）和（56.0±8.0）h,均较H组［（69.3±4.6）h］快。A、B、D、E、F和G组治愈猴数分别为1、3、3、2、2和3只。C、H和I组均未治愈。 结论 磷酸萘酚喹与青蒿素伍用可降低伍用单药剂量,缩短疗程,提高治愈率,两药1:2.5的比例配伍治愈率达100%。

Therapeutic Efficacy of Naphthoquine Phosphate Combined with Artemisinine against Plasmodium knowlesi

Objective To study the antimalarial activity of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi in rhesus monkey.Methods Monkeys were randomly divided into 9 groups(3/group).The monkeys in groups A and B were treated i.g.once daily for 3 days with 6 or 10 mg/kg of naphthoquine phosphate respectively.Those in groups C and D were treated i.g.twice for the 1st day and once for the 2nd and 3rd day with 31.6 or 100 mg/kg of artemisinine respectively.In groups E, F and G, they were t...