| 乳腺癌中血管内皮生长因子和基质金属蛋白酶-9的表达与淋巴结转移的关系 |
| |
| 引用本文： | 瞿峰,粱爽,刘惠民,赵琰龙,时志民. 乳腺癌中血管内皮生长因子和基质金属蛋白酶-9的表达与淋巴结转移的关系[J]. 中国误诊学杂志, 2011, 11(34): 8329-8330 |
| |
| 作者姓名： | 瞿峰 粱爽 刘惠民 赵琰龙 时志民 |
| |
| 作者单位： | 1. 河北工程大学附属医院 056002
2. 河北工程大学医学院 |
| |
| 摘 要： | 目的 检测血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在乳腺癌中的表达情况,研究两者与淋巴结转移的关系.方法 采用免疫组化SP法检测92例乳腺浸润癌中VEGF、MMP-9的表达情况.结果 VEGF蛋白在对照组和乳腺癌组中的阳性表达率分别为5.7％ (3/45)和90.2％(83/92),且VEGF在淋巴结转移组中的阳性表达率(53/55)明显高于无淋巴结转移组(P＜0.05).MMP-9蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为0(0/45)和92.4％ (85/92),而且MMP-9在淋巴结转移组中的阳性表达率(54/55)明显高于无淋巴结转移组(P＜0.05).结论 VEGF、MMP-9蛋白在乳腺癌组织中高表达,且均与淋巴结转移有关(P＜0.05),两者可能在乳腺癌的远处转移中起协同作用.
|
| 关 键 词： | 乳腺肿瘤/代谢 血管内皮生长因子类/代谢 基质金属蛋白酶9/代谢 淋巴转移 |
Relationship between expression of VEGF and MMP-9 in breast carcinoma and lymph node metastasis |
| |
| QU Feng,LIANG Shuang,LIU Hui-min,ZHAO Yah-long,SHI Zhi-min. Relationship between expression of VEGF and MMP-9 in breast carcinoma and lymph node metastasis[J]. Chinese Journal of Misdiagnostics, 2011, 11(34): 8329-8330 |
| |
| Authors: | QU Feng LIANG Shuang LIU Hui-min ZHAO Yah-long SHI Zhi-min |
| |
| Affiliation: | QU Feng,LIANG Shuang,LIU Hui-min,ZHAO Yan-long,SHI Zhi-min Department of Pathology,Hospital Affiliated to Hebei University of Engineering,Handan 056002,China |
| |
| Abstract: | Objective To detect the expression of VEGF and MMP-9 in invasive breast carcinoma,and explore their relationship with lymph node metastasis.Methods The expression of VEGF and MMP-9 was studied in 92 cases of invasive breast carcinoma by SP immunohistochemistry.Results The positive expression of VEGF protein in control group and breast carcinoma group was 6.7%(3/45),90.2%(83/92) respectively,and the positive rate of VEGF in the lymph node metastasis(53/55) was significantly higher than those without lymph no... |
| |
| Keywords: | Breast Neoplasms/metabolism Vascular Endothelial Growth Factors/metabolism Matrix Metalloproteinase 9/metabolism Lymphatic Metastasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
