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| 透明质酸纳米给药载体的研究进展 | |
| 引用本文： | 孙李平,王晓宇,朱全刚,高申. 透明质酸纳米给药载体的研究进展[J]. 药学服务与研究, 2012, 12(4): 265-269 |
| 作者姓名： | 孙李平 王晓宇 朱全刚 高申 |
| 作者单位： | 1. 成都军区司令部直工部,成都,610000 2. 成都军区司令部直工部,成都610000;第二军医大学长海医院药学部,上海200433 3. 第二军医大学长海医院药学部,上海,200433 |
| 摘 要： | 透明质酸(hyaluronic acid,HA)是一种天然多糖,具有无毒性、无免疫原性、无致炎性、生物相容性好、生物可降解等诸多优点,同时还具有靶向性,在药物载体领域广泛应用。本文综述了各种HA纳米给药载体的合成、物理化学特点和生物学性质,重点阐述了其体外靶向能力和体内分布,展望了其发展趋势和应用前景。 |
| 关 键 词： | 透明质酸 纳米粒 药物载体 综述 |
Advances in research on nanoparticle drug delivery system of hyaluronic acid |
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| SUN LiPing , WANG XiaoYu , ZHU QuanGang , GAO Shen. Advances in research on nanoparticle drug delivery system of hyaluronic acid[J]. Pharmaceutical Care and Research, 2012, 12(4): 265-269 | |
| Authors: | SUN LiPing WANG XiaoYu ZHU QuanGang GAO Shen |
| Affiliation: | 1. Subordinate Service Department, Headquarters of Chengdu Military Command of PLA, Chengdu 610000, China 2. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: | Hyaluronic acid （HA） ,a natural polysaccharide possessed such fine qualities as biodegradability,good targeting and biocompatibility, and in the meantime it is non-toxic,non-immunogenic,and non-inflammatory. It is widely used in the field of drug carriers. The synthesis, physicochemical characteristics and biological properties of various HA nanoparticle drug delivery systems are introduced in this paper. This paper focuses on in vitro targeting ability and in viwo distribution of HA nanoparticle drug delivery systems and predict their future development and application. |
| Keywords: | hyaluronic acid nanoparticles drug delivery system review |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |